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Tclin
CSF1R
Macrophage colony-stimulating factor 1 receptor

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286301
  • ENSP00000286301
  • ENSG00000182578
  • ENST00000543093
  • ENSP00000445282

Symbol
  • FMS
  • FMS
  • CSFR
  • FIM2
  • HDLS
  • C-FMS
  • CD115
  • CSF-1R
  • M-CSF-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
biological process
0.99
disease perturbation
0.99
small molecule
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1793.69   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 1631   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1793.69   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 1631   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 839
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9