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Tbio
CSF1
Macrophage colony-stimulating factor 1

Protein Summary
Description
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of mem ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329608
  • ENSP00000327513
  • ENSG00000184371
  • ENST00000369801
  • ENSP00000358816
  • ENST00000369802
  • ENSP00000358817
  • ENST00000420111
  • ENSP00000407317

Symbol
  • MCSF
  • CSF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
biological term
0.93
PubMedID
0.93
transcription factor perturbation
0.91
disease perturbation
0.9


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1807.76   (req: < 5)
Gene RIFs: 163   (req: <= 3)
Antibodies: 753   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1807.76   (req: >= 5)
Gene RIFs: 163   (req: > 3)
Antibodies: 753   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (394)
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.893091611
p_ni:  0.106908381
p_wrong:  8e-9
Data Source:  BioPlex
CSF1R
Tclin
Family:  Kinase
Novelty:  0.00064143
Score:  0.999
Data Source:  Reactome,STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.982
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.976
Data Source:  STRINGDB
IL34
Tbio
Novelty:  0.00838631
Score:  0.974
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.955
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.952
Data Source:  STRINGDB
SPP1
Tbio
Novelty:  0.00014418
Score:  0.95
Data Source:  STRINGDB
CBL
Tbio
Family:  Enzyme
Novelty:  0.00114929
Score:  0.948
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.948
Data Source:  STRINGDB
Nearest Tclin Targets (18)
Explore Nearest Tclin Targets
Pathways (29)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Metabolism of proteins
Reactome
Other interleukin signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-10 signaling
Metabolism of proteins
Other interleukin signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (51)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage colony stimulating factor measurement
1
2
2
86.2
aspartate aminotransferase measurement
2
1
1
16.9
85.7
monocyte count
2
2
3
84.2
creatine kinase measurement
1
1
1
82.6
L lactate dehydrogenase measurement
1
1
1
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage colony stimulating factor measurement
2
86.2
aspartate aminotransferase measurement
1
16.9
85.7
monocyte count
3
84.2
creatine kinase measurement
1
82.6
L lactate dehydrogenase measurement
1
75.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
colony stimulating factor 1
VGNC:510
457127
Macaque
colony stimulating factor 1
702532
Mouse
MGI:1339753
12977
Rat
RGD:621063
78965
Dog
colony stimulating factor 1
VGNC:39652
611795
Species
Name
OMA
EggNOG
Inparanoid
Chimp
colony stimulating factor 1
Macaque
colony stimulating factor 1
Mouse
Rat
Dog
colony stimulating factor 1
Publication Statistics
PubMed Score 1807.76
PubMed score by year
PubTator Score 1439.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title