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Tbio
CRYZL1
Quinone oxidoreductase-like protein 1

Protein Summary
Description
This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381554
  • ENSP00000370966
  • ENSG00000205758
  • ENST00000420072
  • ENSP00000416315

Symbol
  • 4P11
  • 4P11
  • QOH-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.82
gene perturbation
0.81
cell type or tissue
0.78
transcription factor
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
PLXNA4
Tbio
Novelty:  0.01807048
p_int:  0.999999303
p_ni:  4.12e-7
p_wrong:  2.85e-7
Score:  0.29
Data Source:  BioPlex,STRINGDB
IL6R
Tclin
Novelty:  0.00185005
p_int:  0.999997098
p_ni:  0.000002898
p_wrong:  5e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.999995187
p_ni:  0.00000479
p_wrong:  2.3e-8
Data Source:  BioPlex
ITPK1
Tbio
Family:  Kinase
Novelty:  0.02790263
p_int:  0.99971934
p_ni:  0.000280646
p_wrong:  1.5e-8
Score:  0.455
Data Source:  BioPlex,STRINGDB
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.999599451
p_ni:  0.000276654
p_wrong:  0.000123895
Data Source:  BioPlex
FBXL14
Tbio
Novelty:  0.21211079
p_int:  0.999409532
p_ni:  0.000586488
p_wrong:  0.00000398
Score:  0.197
Data Source:  BioPlex,STRINGDB
CFAP52
Tbio
Novelty:  0.23267809
p_int:  0.999385431
p_ni:  0.000564325
p_wrong:  0.000050245
Score:  0.214
Data Source:  BioPlex,STRINGDB
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.998742683
p_ni:  0.001254502
p_wrong:  0.000002815
Data Source:  BioPlex
FRMD7
Tbio
Novelty:  0.01561885
Score:  0.759
Data Source:  STRINGDB
NYX
Tbio
Novelty:  0.0100148
Score:  0.757
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tonsillectomy risk measurement
1
1
0
1.1
30.2
self reported educational attainment
1
1
1
30.2
1
1
0
1.1
24.5
biological sex
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tonsillectomy risk measurement
0
1.1
30.2
self reported educational attainment
1
30.2
0
1.1
24.5
biological sex
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin zeta like 1
VGNC:14657
473974
Macaque
crystallin zeta like 1
698723
Mouse
MGI:1913859
66609
Rat
RGD:1310219
288256
Dog
quinone oxidoreductase-like protein 1
100856647
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin zeta like 1
Macaque
crystallin zeta like 1
Mouse
Rat
Dog
quinone oxidoreductase-like protein 1
Publication Statistics
PubMed Score 18.94
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title