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Tbio
CRYM
Ketimine reductase mu-crystallin

Protein Summary
Description
Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-sy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219599
  • ENSP00000219599
  • ENSG00000103316
  • ENST00000543948
  • ENSP00000440227
  • ENST00000639592
  • ENSP00000490961
  • ENSG00000283922
  • ENST00000640547
  • ENSP00000492104

Symbol
  • THBP
  • THBP
  • DFNA40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
molecular function
0.84
PubMedID
0.8
tissue sample
0.69
disease perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.09   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.09   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
RNF126
Tbio
Family:  Enzyme
Novelty:  0.08123801
p_int:  0.995713107
p_ni:  0.004286893
Score:  0.403
Data Source:  BioPlex,STRINGDB
PIPOX
Tbio
Family:  Enzyme
Novelty:  0.04107707
Score:  0.938
Data Source:  STRINGDB
L3HYPDH
Tdark
Family:  Enzyme
Novelty:  0.35456591
Score:  0.812
Data Source:  STRINGDB
AASDH
Tbio
Family:  Enzyme
Novelty:  0.17181708
Score:  0.775
Data Source:  STRINGDB
CRYZL1
Tbio
Family:  Enzyme
Novelty:  0.04435286
Score:  0.738
Data Source:  STRINGDB
DAO
Tchem
Family:  Enzyme
Novelty:  0.00414923
Score:  0.674
Data Source:  STRINGDB
NTNG2
Tbio
Novelty:  0.02827688
Score:  0.672
Data Source:  STRINGDB
SLC17A8
Tbio
Family:  Transporter
Novelty:  0.00647654
Score:  0.671
Data Source:  STRINGDB
TTR
Tclin
Novelty:  0.0001199
Score:  0.662
Data Source:  STRINGDB
CBLN2
Tbio
Novelty:  0.09853702
Score:  0.661
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Lysine catabolism (R-HSA-71064)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lysine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Lysine catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin mu
VGNC:5746
742586
Macaque
crystallin mu
697588
Mouse
MGI:102675
12971
Rat
RGD:620943
117024
Dog
crystallin mu
VGNC:39648
479818
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin mu
Macaque
crystallin mu
Mouse
Rat
Dog
crystallin mu
Publication Statistics
PubMed Score 51.09
PubMed score by year
PubTator Score 21.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title