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Tbio
CRYGS
Gamma-crystallin S

Protein Summary
Description
Crystallins are the dominant structural components of the vertebrate eye lens. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307944
  • ENSP00000312099
  • ENSG00000213139
  • ENST00000392499
  • ENSP00000376287

Symbol
  • CRYG8
  • CRYG8
  • CTRCT20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.61
virus perturbation
0.55
cell line
0.52
gene perturbation
0.49
tissue sample
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 694.19   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 694.19   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
CXorf40A
Tbio
Novelty:  0.13576501
p_int:  0.999992193
p_ni:  0.000007807
Data Source:  BioPlex
ANKRD36
Tdark
Novelty:  0.48979566
p_int:  0.985464749
p_ni:  0.014535212
p_wrong:  3.9e-8
Data Source:  BioPlex
NDUFAF4
Tclin
Family:  Enzyme
Novelty:  0.10799507
p_int:  0.976215099
p_ni:  0.023784901
Data Source:  BioPlex
RAI2
Tdark
Novelty:  0.09286714
p_int:  0.972576673
p_ni:  0.027419411
p_wrong:  0.000003916
Data Source:  BioPlex
HINT2
Tbio
Novelty:  0.09560851
p_int:  0.867199464
p_ni:  0.132800536
Data Source:  BioPlex
LAIR2
Tbio
Novelty:  0.06117644
p_int:  0.864935618
p_ni:  0.135064378
p_wrong:  4e-9
Data Source:  BioPlex
CRYAB
Tchem
Novelty:  0.00464213
Score:  0.842
Data Source:  STRINGDB
CRYAA2
Tdark
Novelty:  0.01914081
Score:  0.838
Data Source:  STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
Score:  0.838
Data Source:  STRINGDB
BFSP2
Tbio
Novelty:  0.00206411
Score:  0.795
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
3
3
77.2
intraocular pressure measurement
1
1
1
61.4
neutrophil count
1
1
1
6.3
illegal drug consumption
1
1
0
15.7
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
3
77.2
intraocular pressure measurement
1
61.4
neutrophil count
1
6.3
illegal drug consumption
0
15.7
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin gamma S
VGNC:6179
460909
Mouse
MGI:1298216
12970
Rat
RGD:1587483
689897
Dog
crystallin gamma S
VGNC:39646
607506
Horse
crystallin gamma S
VGNC:16887
100059387
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin gamma S
Mouse
Rat
Dog
crystallin gamma S
Horse
crystallin gamma S
Publication Statistics
PubMed Score 694.19
PubMed score by year
PubTator Score 10.05
PubTator score by year
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Related Publications
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PMID
Year
Title