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Tdark
CRYGN
Gamma-crystallin N

Protein Summary
Description
This gene encodes a member of the crystallin family of proteins that are localized to the refractive structure of vertebrate eye lenses. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337323
  • ENSP00000338613
  • ENSG00000127377
  • ENST00000491928
  • ENSP00000420157
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
PubMedID
0.78
cellular component
0.64
tissue
0.54
cell line
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.16   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.16   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
CKM
Tbio
Family:  Kinase
Novelty:  0.00239628
p_int:  0.999509475
p_ni:  0.000395209
p_wrong:  0.000095316
Data Source:  BioPlex
ALOX12B
Tbio
Family:  Enzyme
Novelty:  0.02778552
p_int:  0.809677073
p_ni:  0.190322926
p_wrong:  1e-9
Data Source:  BioPlex
B9D1
Tbio
Novelty:  0.11567839
p_int:  0.77998549
p_ni:  0.000028167
p_wrong:  0.219986343
Data Source:  BioPlex
CRYAA2
Tdark
Novelty:  0.01914081
Score:  0.594
Data Source:  STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
Score:  0.594
Data Source:  STRINGDB
FAM174B
Tdark
Novelty:  0.54823112
Score:  0.584
Data Source:  STRINGDB
TSPO2
Tbio
Novelty:  0.17373697
Score:  0.565
Data Source:  STRINGDB
BFSP1
Tbio
Novelty:  0.01519136
Score:  0.553
Data Source:  STRINGDB
SULT2B1
Tbio
Family:  Enzyme
Novelty:  0.02652128
Score:  0.551
Data Source:  STRINGDB
GRIFIN
Tdark
Novelty:  0.1208389
Score:  0.542
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
64.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
64.3
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin gamma N
VGNC:4324
737768
Macaque
crystallin gamma N
715040
Mouse
MGI:2449167
214301
Dog
crystallin gamma N
VGNC:39645
611008
Cow
crystallin gamma N
VGNC:27742
519041
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin gamma N
Macaque
crystallin gamma N
Mouse
Dog
crystallin gamma N
Cow
crystallin gamma N
Publication Statistics
PubMed Score 3.16
PubMed score by year
PubTator Score 2.50
PubTator score by year
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Related Publications
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PMID
Year
Title