Protein Summary
This gene encodes a member of the crystallin family of proteins that are localized to the refractive structure of vertebrate eye lenses. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
- ENST00000337323
- ENSP00000338613
- ENSG00000127377
- ENST00000491928
- ENSP00000420157
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.85 | ||
PubMedID | 0.78 | ||
cellular component | 0.64 | ||
tissue | 0.54 | ||
cell line | 0.43 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.16 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 45 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.16 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 45 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (23)
CKM
Family: Kinase
Novelty: 0.00239628
p_int: 0.999509475
p_ni: 0.000395209
p_wrong: 0.000095316
Data Source: BioPlex
ALOX12B
Family: Enzyme
Novelty: 0.02778552
p_int: 0.809677073
p_ni: 0.190322926
p_wrong: 1e-9
Data Source: BioPlex
B9D1
Novelty: 0.11567839
p_int: 0.77998549
p_ni: 0.000028167
p_wrong: 0.219986343
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (0)
Disease Associations (null)
GWAS Traits (1)
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1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 2 | 2 | 64.3 | |||||
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1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 64.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | crystallin gamma N | VGNC:4324 | 737768 | |||||
Macaque | crystallin gamma N | 715040 | ||||||
Mouse | MGI:2449167 | 214301 | ||||||
Dog | crystallin gamma N | VGNC:39645 | 611008 | |||||
Cow | crystallin gamma N | VGNC:27742 | 519041 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | crystallin gamma N | |||||
Macaque | crystallin gamma N | |||||
Mouse | ||||||
Dog | crystallin gamma N | |||||
Cow | crystallin gamma N | |||||
Publication Statistics
PubMed Score 3.16
PubMed score by year
PubTator Score 2.50
PubTator score by year
Related Publications
Text Mined References (7)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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