Protein Summary
Crystallins are the dominant structural components of the vertebrate eye lens. This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others. [provided by RefSeq, Jan 2015]
- ENST00000282141
- ENSP00000282141
- ENSG00000163254
- ENST00000646204
- ENSP00000496418
- ENSG00000285011
- CRYG3
- CCL
- CRYG3
- CTRCT2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.63 | ||
cell line | 0.61 | ||
small molecule perturbation | 0.53 | ||
PubMedID | 0.5 | ||
biological term | 0.43 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 743.5 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 154 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 743.5 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 154 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (30)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.2 | 42.3 | ||||||
1 | 1 | 0 | 1.2 | 42.3 | ||||||
1 | 1 | 0 | 1.2 | 42.3 | ||||||
1 | 1 | 0 | 1.2 | 42.3 | ||||||
daytime rest measurement | 1 | 1 | 1 | 10.6 | ||||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 42.3 | |||||
0 | 1.2 | 42.3 | |||||
0 | 1.2 | 42.3 | |||||
0 | 1.2 | 42.3 | |||||
daytime rest measurement | 1 | 10.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | crystallin gamma C | VGNC:151 | 737363 | |||||
Macaque | crystallin, gamma C | 709553 | ||||||
Mouse | MGI:88523 | 12966 | ||||||
Rat | RGD:2421 | 24277 | ||||||
Dog | crystallin, gamma C | 100126770 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | crystallin gamma C | |||||
Macaque | crystallin, gamma C | |||||
Mouse | ||||||
Rat | ||||||
Dog | crystallin, gamma C | |||||
Publication Statistics
PubMed Score 743.50
PubMed score by year
PubTator Score 55.13
PubTator score by year
Related Publications
Text Mined References (42)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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