You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CRYGC
Gamma-crystallin C

Protein Summary
Description
Crystallins are the dominant structural components of the vertebrate eye lens. This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282141
  • ENSP00000282141
  • ENSG00000163254
  • ENST00000646204
  • ENSP00000496418
  • ENSG00000285011

Symbol
  • CRYG3
  • CCL
  • CRYG3
  • CTRCT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.63
cell line
0.61
small molecule perturbation
0.53
PubMedID
0.5
biological term
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 743.5   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 743.5   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
CRYGB
Tbio
Novelty:  0.01359977
p_int:  1
Score:  0.725
Data Source:  BioPlex,STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
Score:  0.879
Data Source:  STRINGDB
CRYAA2
Tdark
Novelty:  0.01914081
Score:  0.855
Data Source:  STRINGDB
CRYAB
Tchem
Novelty:  0.00464213
Score:  0.833
Data Source:  STRINGDB
GJA3
Tbio
Novelty:  0.00638283
Score:  0.8
Data Source:  STRINGDB
BFSP2
Tbio
Novelty:  0.00206411
Score:  0.753
Data Source:  STRINGDB
HSPB2
Tbio
Novelty:  0.00103909
Score:  0.747
Data Source:  STRINGDB
GJA8
Tbio
Novelty:  0.00377739
Score:  0.746
Data Source:  STRINGDB
MIP
Tbio
Novelty:  0.00299543
Score:  0.73
Data Source:  STRINGDB
HSPB1
Tchem
Novelty:  0.00081373
Score:  0.7
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
42.3
1
1
0
1.2
42.3
1
1
0
1.2
42.3
1
1
0
1.2
42.3
daytime rest measurement
1
1
1
10.6
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
42.3
0
1.2
42.3
0
1.2
42.3
0
1.2
42.3
daytime rest measurement
1
10.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin gamma C
VGNC:151
737363
Macaque
crystallin, gamma C
709553
Mouse
MGI:88523
12966
Rat
RGD:2421
24277
Dog
crystallin, gamma C
100126770
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin gamma C
Macaque
crystallin, gamma C
Mouse
Rat
Dog
crystallin, gamma C
Publication Statistics
PubMed Score 743.50
PubMed score by year
PubTator Score 55.13
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title