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Tdark
CRYBG3
Very large A-kinase anchor protein

Protein Summary
Description
Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.89
cellular component
0.84
disease perturbation
0.79
virus perturbation
0.76
gene perturbation
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.38   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 2   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.38   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.999999997
p_ni:  3e-9
Data Source:  BioPlex
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.999999956
p_ni:  4.2e-8
p_wrong:  2e-9
Score:  0.192
Data Source:  BioPlex,STRINGDB
TSSK1B
Tchem
Family:  Kinase
Novelty:  0.01931035
p_int:  0.999998172
p_ni:  0.000001828
Score:  0.234
Data Source:  BioPlex,STRINGDB
MLF1
Tbio
Novelty:  0.0239522
p_int:  0.999948467
p_ni:  0.000051463
p_wrong:  7e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
CRYBG2
Tdark
Novelty:  0.7500462
p_int:  0.999193959
p_ni:  0.000800166
p_wrong:  0.000005875
Score:  0.296
Data Source:  BioPlex,STRINGDB
NPAS1
Tbio
Family:  TF
Novelty:  0.08014425
p_int:  0.990331888
p_ni:  0.007027354
p_wrong:  0.002640758
Score:  0.187
Data Source:  BioPlex,STRINGDB
TP53RK
Tbio
Family:  Kinase
Novelty:  0.04302252
Score:  0.694
Data Source:  STRINGDB
SEH1L
Tbio
Novelty:  0.03666501
Score:  0.647
Data Source:  STRINGDB
MAK16
Tdark
Novelty:  0.07717917
Score:  0.56
Data Source:  STRINGDB
CRYZL1
Tbio
Family:  Enzyme
Novelty:  0.04435286
Score:  0.537
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 6.38
PubMed score by year
PubTator Score 1.25
PubTator score by year
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Related Publications
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PMID
Year
Title