You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
CRYBG2
Beta/gamma crystallin domain-containing protein 2

Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.57   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.57   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
DDX3Y
Tbio
Family:  Enzyme
p_int:  0.999999996
p_ni:  1e-9
p_wrong:  3e-9
Data Source:  BioPlex
NEIL3
Tbio
Family:  Enzyme
Novelty:  0.02068317
p_int:  0.999950273
p_ni:  3.1e-8
p_wrong:  0.000049695
Data Source:  BioPlex
MGA
Tbio
Family:  TF
Novelty:  0.08965274
p_int:  0.999857734
p_ni:  0.000142267
Score:  0.311
Data Source:  BioPlex,STRINGDB
KLHDC3
Tbio
Novelty:  0.63840156
p_int:  0.99962401
p_ni:  0.000375982
p_wrong:  9e-9
Data Source:  BioPlex
CRYBG3
Tdark
Family:  Enzyme
Novelty:  0.24063491
p_int:  0.999193959
p_ni:  0.000800166
p_wrong:  0.000005875
Score:  0.296
Data Source:  BioPlex,STRINGDB
ATXN2
Tbio
Novelty:  0.00373116
p_int:  0.998854666
p_ni:  0.001145334
Data Source:  BioPlex
ZZZ3
Tbio
Family:  TF
Novelty:  0.23862921
p_int:  0.998595715
p_ni:  0.001404285
p_wrong:  1e-9
Data Source:  BioPlex
EIF4G3
Tbio
Novelty:  0.03002723
p_int:  0.997326998
p_ni:  0.002673002
Data Source:  BioPlex
YEATS2
Tbio
Novelty:  0.17584498
p_int:  0.997038791
p_ni:  0.002961209
Data Source:  BioPlex
LRIF1
Tdark
Novelty:  0.26861958
p_int:  0.99583561
p_ni:  0.004164305
p_wrong:  8.5e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
3
3
83.1
appendicular lean mass
2
1
2
80.7
monocyte percentage of leukocytes
2
2
2
78
eosinophil count
3
2
3
65.9
forced expiratory volume
1
1
1
51.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
83.1
appendicular lean mass
2
80.7
monocyte percentage of leukocytes
2
78
eosinophil count
3
65.9
forced expiratory volume
1
51.8
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1334463
230806
Dog
crystallin beta-gamma domain containing 2
VGNC:39643
612166
Cow
crystallin beta-gamma domain containing 2
VGNC:27740
507142
Opossum
crystallin beta-gamma domain containing 2
100015815
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
crystallin beta-gamma domain containing 2
Cow
crystallin beta-gamma domain containing 2
Opossum
crystallin beta-gamma domain containing 2
Publication Statistics
PubMed Score 1.57
PubMed score by year
PubTator Score 0.25
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title