Protein Summary
Crystallins are the dominant structural components of the vertebrate eye lens. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of the vertebrate eye, which function to maintain the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also defined as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group but absent in the acidic group). Beta-crystallins form ag ...more
- ENST00000295728
- ENSP00000295728
- ENSG00000163499
- ENST00000392096
- ENSP00000375946
- CTRCT42
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.77 | ||
virus perturbation | 0.76 | ||
PubMedID | 0.54 | ||
transcription factor | 0.5 | ||
cell line | 0.46 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.82 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 49 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.82 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 49 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (30)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (3)
Functions (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
balding measurement | 1 | 2 | 2 | 91.5 | |||||
body height | 4 | 7 | 7 | 87.6 | |||||
1 | 1 | 0 | 3.3 | 82.6 | |||||
1 | 2 | 2 | 78.7 | ||||||
hair shape measurement | 1 | 1 | 1 | 77.3 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
balding measurement | 2 | 91.5 | |||||
body height | 7 | 87.6 | |||||
0 | 3.3 | 82.6 | |||||
2 | 78.7 | ||||||
hair shape measurement | 1 | 77.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | crystallin beta A2 | VGNC:148 | 459955 | |||||
Mouse | MGI:104336 | 12958 | ||||||
Rat | RGD:628768 | 286925 | ||||||
Dog | crystallin beta A2 | VGNC:39637 | 488531 | |||||
Horse | crystallin beta A2 | VGNC:16884 | 100058931 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | crystallin beta A2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | crystallin beta A2 | |||||
Horse | crystallin beta A2 | |||||
Publication Statistics
PubMed Score 9.82
PubMed score by year
PubTator Score 3.31
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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