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Tbio
CRYBA1
Beta-crystallin A3

Protein Summary
Description
Crystallins are the dominant structural components of the vertebrate eye lens. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of dif ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225387
  • ENSP00000225387
  • ENSG00000108255

Symbol
  • CRYB1
  • CRYB1
  • CTRCT10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
gene perturbation
0.69
PubMedID
0.55
biological term
0.46
tissue sample
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.48   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.48   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
CRYAA
Tchem
Novelty:  0.01914081
Score:  0.922
Data Source:  STRINGDB
CRYAA2
Tdark
Novelty:  0.01914081
Score:  0.905
Data Source:  STRINGDB
CRYAB
Tchem
Novelty:  0.00464213
Score:  0.873
Data Source:  STRINGDB
GJA3
Tbio
Novelty:  0.00638283
Score:  0.818
Data Source:  STRINGDB
BFSP2
Tbio
Novelty:  0.00206411
Score:  0.784
Data Source:  STRINGDB
GJA8
Tbio
Novelty:  0.00377739
Score:  0.775
Data Source:  STRINGDB
LIM2
Tbio
Novelty:  0.01252353
Score:  0.748
Data Source:  STRINGDB
CRYBB1
Tbio
Novelty:  0.01083645
Score:  0.721
Data Source:  STRINGDB
HSF4
Tbio
Family:  TF
Novelty:  0.01736563
Score:  0.709
Data Source:  STRINGDB
BFSP1
Tbio
Novelty:  0.01519136
Score:  0.703
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
63.7
leukocyte count
1
1
1
63.4
2
2
2
48.5
smoking status measurement
1
1
1
44.2
smoking behaviour measurement
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
63.7
leukocyte count
1
63.4
2
48.5
smoking status measurement
1
44.2
smoking behaviour measurement
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin beta A1
VGNC:9250
468199
Macaque
crystallin beta A1
716819
Mouse
MGI:88518
12957
Rat
RGD:2415
25583
Dog
crystallin beta A1
VGNC:39636
491178
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin beta A1
Macaque
crystallin beta A1
Mouse
Rat
Dog
crystallin beta A1
Publication Statistics
PubMed Score 38.48
PubMed score by year
PubTator Score 24.17
PubTator score by year
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Related Publications
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PMID
Year
Title