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Tdark
CRYAA2
Alpha-crystallin A2 chain

Protein Summary
Description
Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000619537
  • ENSP00000482816
  • ENSG00000276076
  • ENST00000624932
  • ENSP00000485302

Symbol
  • CRYAA
  • CRYAA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.74   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.74   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
CRYBB1
Tbio
Novelty:  0.01083645
Score:  0.94
Data Source:  STRINGDB
CRYBB2
Tbio
Novelty:  0.00721869
Score:  0.934
Data Source:  STRINGDB
CRYAB
Tchem
Novelty:  0.00464213
Score:  0.913
Data Source:  STRINGDB
CRYBA1
Tbio
Novelty:  0.02788955
Score:  0.905
Data Source:  STRINGDB
CRYBB3
Tbio
Novelty:  0.0455879
Score:  0.876
Data Source:  STRINGDB
CRYBA4
Tbio
Novelty:  0.03692663
Score:  0.863
Data Source:  STRINGDB
CRYGC
Tbio
Novelty:  0.00083924
Score:  0.855
Data Source:  STRINGDB
GJA3
Tbio
Novelty:  0.00638283
Score:  0.85
Data Source:  STRINGDB
CRYGS
Tbio
Novelty:  0.00145068
Score:  0.838
Data Source:  STRINGDB
GJA8
Tbio
Novelty:  0.00377739
Score:  0.835
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 60.74
PubMed score by year
PubTator Score 2.39
PubTator score by year
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Related Publications
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PMID
Year
Title