Tchem CRYAA Alpha-crystallin A chain

Protein Summary

Description

Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

Uniprot Accession IDs

• P02489
• Q53X53

Gene Name

• CRYAA

Ensembl ID

• ENST00000291554
• ENSP00000291554
• ENSG00000160202

Symbol

• CRYA1
• HSPB4
• CRT1
• CRTL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.72
biological term	0.64
cellular component	0.54
hub protein	0.53
cell type or tissue	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.91   (req: < 5)

Gene RIFs: 138   (req: <= 3)

Antibodies: 409   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.91   (req: >= 5)

Gene RIFs: 138   (req: > 3)

Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0