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Tbio
CRX
Cone-rod homeobox protein

Protein Summary
Description
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221996
  • ENSP00000221996
  • ENSG00000105392
  • ENST00000539067
  • ENSP00000445565

Symbol
  • CORD2
  • CRD
  • LCA7
  • OTX3
  • CORD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
kinase perturbation
0.81
biological process
0.72
protein domain
0.58
cell line
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.83   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.83   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
NRL
Tbio
Family:  TF
Novelty:  0.00197314
Score:  0.965
Data Source:  STRINGDB
NR2E3
Tchem
Family:  NR
Novelty:  0.00643343
Score:  0.947
Data Source:  STRINGDB
ATXN7
Tbio
Novelty:  0.00323014
Score:  0.943
Data Source:  STRINGDB
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.884
Data Source:  STRINGDB
RAX2
Tbio
Family:  TF
Novelty:  0.04942999
Score:  0.882
Data Source:  STRINGDB
AIPL1
Tbio
Novelty:  0.01436649
Score:  0.8
Data Source:  STRINGDB
GUCY2D
Tbio
Family:  Kinase
Novelty:  0.00578343
Score:  0.792
Data Source:  STRINGDB
FIZ1
Tdark
Family:  TF
Novelty:  0.30861253
Score:  0.785
Data Source:  STRINGDB
RCVRN
Tbio
Novelty:  0.00266222
Score:  0.758
Data Source:  STRINGDB
CRB1
Tbio
Novelty:  0.00560299
Score:  0.733
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Circadian rhythm related genes
WikiPathways
Circadian rhythm related genes
WikiPathways
Circadian rhythm related genes
WikiPathways
Signaling Pathways in Glioblastoma
WikiPathways
Common Pathways Underlying Drug Addiction
Name
Explore in Pharos
Explore in Source
Circadian rhythm related genes
Circadian rhythm related genes
Circadian rhythm related genes
Signaling Pathways in Glioblastoma
Common Pathways Underlying Drug Addiction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
7
5
8
98.6
blood metabolite measurement
2
4
9
98.2
serum metabolite measurement
1
1
2
83.1
1
1
0
1.2
80.3
alkaline phosphatase measurement
1
1
1
72.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
8
98.6
blood metabolite measurement
9
98.2
serum metabolite measurement
2
83.1
0
1.2
80.3
alkaline phosphatase measurement
1
72.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1194883
12951
Rat
RGD:620511
60446
Dog
cone-rod homeobox
VGNC:39632
403577
Cow
cone-rod homeobox
280756
Pig
cone-rod homeobox
100520079
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cone-rod homeobox
Cow
cone-rod homeobox
Pig
cone-rod homeobox
Publication Statistics
PubMed Score 374.83
PubMed score by year
PubTator Score 200.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title