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Tbio
CRTAC1
Cartilage acidic protein 1

Protein Summary
Description
This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370591
  • ENSP00000359623
  • ENSG00000095713
  • ENST00000370597
  • ENSP00000359629

Symbol
  • ASPIC1
  • CEP68
  • ASPIC
  • CEP68
  • LOTUS
  • ASPIC1
  • CEP-68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.71
PubMedID
0.66
transcription factor
0.63
protein domain
0.58
disease perturbation
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.91   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.91   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
ZMYM6
Tdark
Novelty:  0.4933879
p_int:  0.999958043
p_ni:  0.000041957
Data Source:  BioPlex
A2M
Tbio
Novelty:  0.00070446
p_int:  0.999920278
p_ni:  0.000079719
p_wrong:  3e-9
Score:  0.286
Data Source:  BioPlex,STRINGDB
CFP
Tbio
Novelty:  0.00063251
p_int:  0.99979194
p_ni:  0.00020805
p_wrong:  9e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
TXNDC16
Tdark
Novelty:  0.25365147
p_int:  0.999742816
p_ni:  0.000256036
p_wrong:  0.000001148
Data Source:  BioPlex
WFDC2
Tbio
Novelty:  0.0136923
p_int:  0.998417157
p_ni:  0.000982927
p_wrong:  0.000599916
Score:  0.179
Data Source:  BioPlex,STRINGDB
MAPRE2
Tbio
Novelty:  0.00692773
p_int:  0.995650652
p_ni:  0.004328881
p_wrong:  0.000020467
Score:  0.787
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.954310625
p_ni:  0.045689375
Data Source:  BioPlex
MTO1
Tbio
Novelty:  0.0229161
p_int:  0.946298356
p_ni:  0.053701644
Data Source:  BioPlex
TRAPPC10
Tbio
Novelty:  0.03433058
p_int:  0.938255607
p_ni:  0.061743242
p_wrong:  0.000001151
Data Source:  BioPlex
BRIP1
Tbio
Novelty:  0.03886334
p_int:  0.936053551
p_ni:  0.063939482
p_wrong:  0.000006967
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
3
3
87
body height
1
1
1
70.2
high density lipoprotein cholesterol measurement
2
2
2
69.6
grip strength measurement
2
2
2
65.7
triglyceride measurement
1
1
1
65.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
87
body height
1
70.2
high density lipoprotein cholesterol measurement
2
69.6
grip strength measurement
2
65.7
triglyceride measurement
1
65.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cartilage acidic protein 1
VGNC:1606
450660
Macaque
cartilage acidic protein 1
707486
Mouse
MGI:1920082
72832
Rat
RGD:621085
171438
Dog
cartilage acidic protein 1
VGNC:39629
608827
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cartilage acidic protein 1
Macaque
cartilage acidic protein 1
Mouse
Rat
Dog
cartilage acidic protein 1
Publication Statistics
PubMed Score 14.91
PubMed score by year
PubTator Score 11.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title