Tbio CRP C-reactive protein

Protein Summary

Description

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P02741
• A8K078
• D3DVD9
• D3DVE0
• Q08AK3
• Q8WW75

Gene Name

• CRP

Ensembl ID

• ENST00000255030
• ENSP00000255030
• ENSG00000132693
• ENST00000368112
• ENSP00000357093

Symbol

• PTX1
• PTX1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
chemical	0.99
molecular function	0.95
biological process	0.89
disease	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71362.89   (req: < 5)

Gene RIFs: 1888   (req: <= 3)

Antibodies: 1765   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71362.89   (req: >= 5)

Gene RIFs: 1888   (req: > 3)

Antibodies: 1765   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (407)

Explore Interacting Targets

1 – 10 of 407

• See Interactions on String-DB

CHST3

Tbio

Family:  Enzyme

Novelty:  0.01744095

p_int:  0.99999996

p_ni:  3.8e-8

p_wrong:  1e-9

Score:  0.196

Data Source:  BioPlex,STRINGDB

LAMA5

Tbio

Novelty:  0.02247145

p_int:  0.999999179

p_ni:  8.21e-7

Score:  0.157

Data Source:  BioPlex,STRINGDB

PRSS23

Tbio

Family:  Enzyme

Novelty:  0.12685614

p_int:  0.999998772

p_ni:  0.000001217

p_wrong:  1e-8

Data Source:  BioPlex

CEMIP2

Tbio

Novelty:  0.04698236

p_int:  0.999991947

p_ni:  0.000008053

Data Source:  BioPlex

AGRN

Tbio

Novelty:  0.00156441

p_int:  0.999966555

p_ni:  0.000033443

p_wrong:  2e-9

Score:  0.219

Data Source:  BioPlex,STRINGDB

SPTB

Tbio

Novelty:  0.00467504

p_int:  0.999872012

p_ni:  0.000036675

p_wrong:  0.000091313

Score:  0.272

Data Source:  BioPlex,STRINGDB

GDF11

Tclin

Novelty:  0.00585981

p_int:  0.999332903

p_ni:  0.000667051

p_wrong:  4.5e-8

Score:  0.185

Data Source:  BioPlex,STRINGDB

C1GALT1

Tbio

Family:  Enzyme

Novelty:  0.01191596

p_int:  0.999267601

p_ni:  0.00024213

p_wrong:  0.000490269

Score:  0.179

Data Source:  BioPlex,STRINGDB

UBR3

Tbio

Family:  Enzyme

Novelty:  0.14930754

p_int:  0.999129546

p_ni:  0.000870454

Data Source:  BioPlex

QSOX1

Tbio

Family:  Enzyme

Novelty:  0.02152583

p_int:  0.998767534

p_ni:  0.001232412

p_wrong:  5.4e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (14)

Reactome (6)

PathwayCommons (2)

WikiPathways (6)

Classical antibody-mediated complement activation (R-HSA-173623)

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5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Classical antibody-mediated complement activation	83 targets	R-HSA-173623
Reactome	Complement cascade	133 targets	R-HSA-166658
Reactome	Creation of C4 and C2 activators	91 targets	R-HSA-166786
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Initial triggering of complement	98 targets	R-HSA-166663

Name	Explore in Pharos	Explore in Source
Classical antibody-mediated complement activation	83 targets	R-HSA-173623
Complement cascade	133 targets	R-HSA-166658
Creation of C4 and C2 activators	91 targets	R-HSA-166786
Immune System	2246 targets	R-HSA-168256
Initial triggering of complement	98 targets	R-HSA-166663

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (20)

Functions (6)

Components (2)

Processes (12)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Direct Assay (IDA)	BHF-UCL
complement component C1q binding	Inferred from Direct Assay (IDA)	BHF-UCL
low-density lipoprotein particle binding	Inferred from Direct Assay (IDA)	BHF-UCL
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
low-density lipoprotein particle receptor binding	Inferred from Physical Interaction (IPI)	AgBase
choline binding	Traceable Author Statement (TAS)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
C-reactive protein measurement	EFO_0004458	21	44	61	4	100
erythropoetin measurement	EFO_0008391	1	1	1		75.5
inflammatory response	GO_0006954	1	1	1		32.8
triglyceride measurement	EFO_0004530	1	1	1		32.8
glucose measurement	EFO_0004468	1	1	1		32.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
C-reactive protein measurement	EFO_0004458	61	4	100
erythropoetin measurement	EFO_0008391	1		75.5
inflammatory response	GO_0006954	1		32.8
triglyceride measurement	EFO_0004530	1		32.8
glucose measurement	EFO_0004468	1		32.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acute phase
Alternative splicing
Calcium
Complete proteome
Direct protein sequencing
Disulfide bond
Metal-binding
Pyrrolidone carboxylic acid
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
C-reactive protein measurement
erythropoetin measurement
glucose measurement
granulocyte count
inflammatory biomarker measurement
inflammatory response
insulin measurement
triglyceride measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	C-reactive protein	VGNC:14363	457428
Macaque	C-reactive protein		719454
Mouse	C-reactive protein, pentraxin-related	MGI:88512	12944
Rat	C-reactive protein	RGD:2411	25419
Dog	C-reactive protein	VGNC:39628	488629

Species	Name	OMA	EggNOG	Inparanoid
Chimp	C-reactive protein
Macaque	C-reactive protein
Mouse	C-reactive protein, pentraxin-related
Rat	C-reactive protein
Dog	C-reactive protein

Publication Statistics

PubMed Score 71362.89

PubMed score by year

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PubTator Score 37565.49

PubTator score by year

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Related Publications

Text Mined References (2017)

GeneRif Annotations (1888)

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PMID	Year	Title