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Tbio
CRP
C-reactive protein

Protein Summary
Description
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255030
  • ENSP00000255030
  • ENSG00000132693
  • ENST00000368112
  • ENSP00000357093

Symbol
  • PTX1
  • PTX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
0.99
molecular function
0.95
biological process
0.89
disease
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71362.89   (req: < 5)
Gene RIFs: 1888   (req: <= 3)
Antibodies: 1765   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71362.89   (req: >= 5)
Gene RIFs: 1888   (req: > 3)
Antibodies: 1765   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (407)
CHST3
Tbio
Family:  Enzyme
Novelty:  0.01744095
p_int:  0.99999996
p_ni:  3.8e-8
p_wrong:  1e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
LAMA5
Tbio
Novelty:  0.02247145
p_int:  0.999999179
p_ni:  8.21e-7
Score:  0.157
Data Source:  BioPlex,STRINGDB
PRSS23
Tbio
Family:  Enzyme
Novelty:  0.12685614
p_int:  0.999998772
p_ni:  0.000001217
p_wrong:  1e-8
Data Source:  BioPlex
CEMIP2
Tbio
Novelty:  0.04698236
p_int:  0.999991947
p_ni:  0.000008053
Data Source:  BioPlex
AGRN
Tbio
Novelty:  0.00156441
p_int:  0.999966555
p_ni:  0.000033443
p_wrong:  2e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
SPTB
Tbio
Novelty:  0.00467504
p_int:  0.999872012
p_ni:  0.000036675
p_wrong:  0.000091313
Score:  0.272
Data Source:  BioPlex,STRINGDB
GDF11
Tclin
Novelty:  0.00585981
p_int:  0.999332903
p_ni:  0.000667051
p_wrong:  4.5e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
C1GALT1
Tbio
Family:  Enzyme
Novelty:  0.01191596
p_int:  0.999267601
p_ni:  0.00024213
p_wrong:  0.000490269
Score:  0.179
Data Source:  BioPlex,STRINGDB
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.999129546
p_ni:  0.000870454
Data Source:  BioPlex
QSOX1
Tbio
Family:  Enzyme
Novelty:  0.02152583
p_int:  0.998767534
p_ni:  0.001232412
p_wrong:  5.4e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Classical antibody-mediated complement activation (R-HSA-173623)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Classical antibody-mediated complement activation
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Immune System
Reactome
Initial triggering of complement
Name
Explore in Pharos
Explore in Source
Classical antibody-mediated complement activation
Complement cascade
Creation of C4 and C2 activators
Immune System
Initial triggering of complement
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
AgBase
Traceable Author Statement (TAS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
21
44
61
4
100
erythropoetin measurement
1
1
1
75.5
inflammatory response
1
1
1
32.8
triglyceride measurement
1
1
1
32.8
glucose measurement
1
1
1
32.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
61
4
100
erythropoetin measurement
1
75.5
inflammatory response
1
32.8
triglyceride measurement
1
32.8
glucose measurement
1
32.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-reactive protein
VGNC:14363
457428
Macaque
C-reactive protein
719454
Mouse
MGI:88512
12944
Rat
RGD:2411
25419
Dog
C-reactive protein
VGNC:39628
488629
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-reactive protein
Macaque
C-reactive protein
Mouse
Rat
Dog
C-reactive protein
Publication Statistics
PubMed Score 71362.89
PubMed score by year
PubTator Score 37565.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title