Protein Summary
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
- ENST00000255030
- ENSP00000255030
- ENSG00000132693
- ENST00000368112
- ENSP00000357093
- PTX1
- PTX1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
chemical | 0.99 | ||
molecular function | 0.95 | ||
biological process | 0.89 | ||
disease | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71362.89 (req: < 5)
Gene RIFs: 1888 (req: <= 3)
Antibodies: 1765 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71362.89 (req: >= 5)
Gene RIFs: 1888 (req: > 3)
Antibodies: 1765 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (407)
CHST3
Family: Enzyme
Novelty: 0.01744095
p_int: 0.99999996
p_ni: 3.8e-8
p_wrong: 1e-9
Score: 0.196
Data Source: BioPlex,STRINGDB
LAMA5
Novelty: 0.02247145
p_int: 0.999999179
p_ni: 8.21e-7
Score: 0.157
Data Source: BioPlex,STRINGDB
PRSS23
Family: Enzyme
Novelty: 0.12685614
p_int: 0.999998772
p_ni: 0.000001217
p_wrong: 1e-8
Data Source: BioPlex
AGRN
Novelty: 0.00156441
p_int: 0.999966555
p_ni: 0.000033443
p_wrong: 2e-9
Score: 0.219
Data Source: BioPlex,STRINGDB
SPTB
Novelty: 0.00467504
p_int: 0.999872012
p_ni: 0.000036675
p_wrong: 0.000091313
Score: 0.272
Data Source: BioPlex,STRINGDB
GDF11
Novelty: 0.00585981
p_int: 0.999332903
p_ni: 0.000667051
p_wrong: 4.5e-8
Score: 0.185
Data Source: BioPlex,STRINGDB
C1GALT1
Family: Enzyme
Novelty: 0.01191596
p_int: 0.999267601
p_ni: 0.00024213
p_wrong: 0.000490269
Score: 0.179
Data Source: BioPlex,STRINGDB
UBR3
Family: Enzyme
Novelty: 0.14930754
p_int: 0.999129546
p_ni: 0.000870454
Data Source: BioPlex
QSOX1
Family: Enzyme
Novelty: 0.02152583
p_int: 0.998767534
p_ni: 0.001232412
p_wrong: 5.4e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (14)
Reactome (6)
PathwayCommons (2)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Classical antibody-mediated complement activation | ||||
Reactome | Complement cascade | ||||
Reactome | Creation of C4 and C2 activators | ||||
Reactome | Immune System | ||||
Reactome | Initial triggering of complement | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Classical antibody-mediated complement activation | ||||
Complement cascade | ||||
Creation of C4 and C2 activators | ||||
Immune System | ||||
Initial triggering of complement | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (6)
Components (2)
Processes (12)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | AgBase | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 21 | 44 | 61 | 4 | 100 | ||||
erythropoetin measurement | 1 | 1 | 1 | 75.5 | |||||
inflammatory response | 1 | 1 | 1 | 32.8 | |||||
triglyceride measurement | 1 | 1 | 1 | 32.8 | |||||
glucose measurement | 1 | 1 | 1 | 32.8 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
C-reactive protein measurement | 61 | 4 | 100 | ||||
erythropoetin measurement | 1 | 75.5 | |||||
inflammatory response | 1 | 32.8 | |||||
triglyceride measurement | 1 | 32.8 | |||||
glucose measurement | 1 | 32.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | C-reactive protein | VGNC:14363 | 457428 | |||||
Macaque | C-reactive protein | 719454 | ||||||
Mouse | MGI:88512 | 12944 | ||||||
Rat | RGD:2411 | 25419 | ||||||
Dog | C-reactive protein | VGNC:39628 | 488629 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | C-reactive protein | |||||
Macaque | C-reactive protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | C-reactive protein | |||||
Publication Statistics
PubMed Score 71362.89
PubMed score by year
PubTator Score 37565.49
PubTator score by year
Related Publications
Text Mined References (2017)
GeneRif Annotations (1888)
Items per page:
0 of 0
PMID | Year | Title |
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