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Tbio
CRNN
Cornulin

Protein Summary
Description
Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271835
  • ENSP00000271835
  • ENSG00000143536

Symbol
  • C1orf10
  • DRC1
  • PDRC1
  • SEP53
  • DRC1
  • PDRC1
  • SEP53
  • C1orf10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.7
disease
0.51
cell line
0.5
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.82   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.82   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
HSF2
Tbio
Family:  TF
Novelty:  0.06458223
p_int:  0.999970094
p_ni:  0.000029906
Data Source:  BioPlex
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.999904864
p_ni:  0.000095136
Data Source:  BioPlex
TNFRSF19
Tbio
Novelty:  0.01295599
p_int:  0.999264311
p_ni:  0.000735689
Data Source:  BioPlex
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.999206702
p_ni:  0.000793298
Data Source:  BioPlex
SSX2IP
Tbio
Novelty:  0.01381625
p_int:  0.996755429
p_ni:  0.0032281
p_wrong:  0.000016471
Score:  0.187
Data Source:  BioPlex,STRINGDB
NSL1
Tbio
Novelty:  0.01396984
p_int:  0.996132913
p_ni:  0.003867086
Data Source:  BioPlex
KIR2DS2
Tdark
p_int:  0.995937358
p_ni:  0.004062642
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.995434008
p_ni:  0.004563459
p_wrong:  0.000002533
Data Source:  BioPlex
OMP
Tbio
Novelty:  0.00286211
p_int:  0.990771534
p_ni:  0.009228291
p_wrong:  1.74e-7
Data Source:  BioPlex
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.98754257
p_ni:  0.01245743
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
4
7
8
98.6
5
2
2
1.2
94.6
7
3
0
1.3
91.9
4
4
0
1.5
91.2
age at onset
1
1
1
86.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
8
98.6
2
1.2
94.6
0
1.3
91.9
0
1.5
91.2
age at onset
1
86.8
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cornulin
VGNC:10590
100609271
Macaque
cornulin
712894
Mouse
MGI:2685861
381457
Rat
RGD:1311778
295186
Dog
cornulin
VGNC:39626
100686283
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cornulin
Macaque
cornulin
Mouse
Rat
Dog
cornulin
Publication Statistics
PubMed Score 68.82
PubMed score by year
PubTator Score 26.48
PubTator score by year
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Related Publications
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PMID
Year
Title