Protein Summary
Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]
- ENST00000271835
- ENSP00000271835
- ENSG00000143536
- C1orf10
- DRC1
- PDRC1
- SEP53
- DRC1
- PDRC1
- SEP53
- C1orf10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.73 | ||
cell type or tissue | 0.7 | ||
disease | 0.51 | ||
cell line | 0.5 | ||
metabolite | 0.45 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.82 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 124 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.82 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 124 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (62)
SSX2IP
Novelty: 0.01381625
p_int: 0.996755429
p_ni: 0.0032281
p_wrong: 0.000016471
Score: 0.187
Data Source: BioPlex,STRINGDB
FTH1
Novelty: 0.000863
p_int: 0.995434008
p_ni: 0.004563459
p_wrong: 0.000002533
Data Source: BioPlex
OMP
Novelty: 0.00286211
p_int: 0.990771534
p_ni: 0.009228291
p_wrong: 1.74e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 4 | 7 | 8 | 98.6 | |||||
5 | 2 | 2 | 1.2 | 94.6 | |||||
7 | 3 | 0 | 1.3 | 91.9 | |||||
4 | 4 | 0 | 1.5 | 91.2 | |||||
age at onset | 1 | 1 | 1 | 86.8 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 8 | 98.6 | |||||
2 | 1.2 | 94.6 | |||||
0 | 1.3 | 91.9 | |||||
0 | 1.5 | 91.2 | |||||
age at onset | 1 | 86.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cornulin | VGNC:10590 | 100609271 | |||||
Macaque | cornulin | 712894 | ||||||
Mouse | MGI:2685861 | 381457 | ||||||
Rat | RGD:1311778 | 295186 | ||||||
Dog | cornulin | VGNC:39626 | 100686283 | |||||
Publication Statistics
PubMed Score 68.82
PubMed score by year
PubTator Score 26.48
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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