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Tbio
CRMP1
Dihydropyrimidinase-related protein 1

Protein Summary
Description
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis. This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324989
  • ENSP00000321606
  • ENSG00000072832
  • ENST00000397890
  • ENSP00000380987

Symbol
  • DPYSL1
  • ULIP3
  • DRP1
  • DRP-1
  • CRMP-1
  • DPYSL1
  • ULIP-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
PubMedID
0.8
kinase
0.77
hub protein
0.67
transcription factor
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.24   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.24   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
DPYSL3
Tbio
Family:  Enzyme
Novelty:  0.01284077
p_int:  0.999999984
p_ni:  1.6e-8
Score:  0.989
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999986472
p_ni:  0.000013528
Data Source:  BioPlex
DPYSL4
Tbio
Family:  Enzyme
Novelty:  0.0449179
p_int:  0.999965067
p_ni:  0.000034933
Score:  0.935
Data Source:  BioPlex,STRINGDB
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.999680793
p_ni:  0.000319162
p_wrong:  4.5e-8
Data Source:  BioPlex
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999618732
p_ni:  0.000381267
p_wrong:  1e-9
Data Source:  BioPlex
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.999477214
p_ni:  0.000522754
p_wrong:  3.2e-8
Data Source:  BioPlex
ARMC1
Tbio
Novelty:  0.02018109
p_int:  0.998580407
p_ni:  0.001419591
p_wrong:  2e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
RRP7A
Tbio
Novelty:  0.11315285
p_int:  0.992442304
p_ni:  0.007557696
Score:  0.305
Data Source:  BioPlex,STRINGDB
PITHD1
Tdark
Novelty:  0.32046117
p_int:  0.988691706
p_ni:  0.011308294
Score:  0.187
Data Source:  BioPlex,STRINGDB
EIF4EBP1
Tbio
Novelty:  0.00098313
p_int:  0.972456069
p_ni:  0.027543931
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
CRMPs in Sema3A signaling
Developmental Biology
Semaphorin interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
0
5.8
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
0
5.8
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collapsin response mediator protein 1
VGNC:584
750614
Macaque
collapsin response mediator protein 1
711349
Mouse
MGI:107793
12933
Rat
RGD:2407
25415
Dog
collapsin response mediator protein 1
VGNC:39624
479097
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collapsin response mediator protein 1
Macaque
collapsin response mediator protein 1
Mouse
Rat
Dog
collapsin response mediator protein 1
Publication Statistics
PubMed Score 55.24
PubMed score by year
PubTator Score 205.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title