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Tbio
CRLF1
Cytokine receptor-like factor 1

Protein Summary
Description
Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development. This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392386
  • ENSP00000376188
  • ENSG00000006016

Symbol
  • CLF
  • NR6
  • CISS
  • CISS1
  • CLF-1
  • zcytor5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
PubMedID
0.9
transcription factor perturbation
0.68
biological process
0.59
transcription factor
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.22   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.22   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.996732599
p_ni:  6.18e-7
p_wrong:  0.003266783
Score:  0.188
Data Source:  BioPlex,STRINGDB
CLCF1
Tbio
Novelty:  0.03134749
Score:  0.993
Data Source:  Reactome,STRINGDB
CNTFR
Tbio
Novelty:  0.0188716
Score:  0.953
Data Source:  Reactome,STRINGDB
IL27
Tbio
Novelty:  0.01469348
Score:  0.939
Data Source:  Reactome,STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.929
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.928
Data Source:  Reactome,STRINGDB
LIFR
Tbio
Novelty:  0.00514085
Score:  0.92
Data Source:  Reactome,STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.915
Data Source:  STRINGDB
IL6ST
Tclin
Novelty:  0.01026472
Score:  0.902
Data Source:  Reactome,STRINGDB
REX1BD
Tdark
Novelty:  2.32988717
Score:  0.804
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-27 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IL-6-type cytokine receptor ligand interactions
Immune System
Interleukin-12 family signaling
Interleukin-27 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
2
2
89.7
Oral ulcer
1
1
0
1.1
73
blood metabolite measurement
1
1
1
60.2
creatinine measurement
1
1
1
59.9
3
3
1
1.1
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
89.7
Oral ulcer
0
1.1
73
blood metabolite measurement
1
60.2
creatinine measurement
1
59.9
1
1.1
57.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytokine receptor like factor 1
VGNC:10199
735722
Mouse
MGI:1340030
12931
Rat
RGD:1311371
290655
Dog
cytokine receptor like factor 1
VGNC:39620
484818
Horse
cytokine receptor like factor 1 [Source:HGNC Symbol;Acc:HGNC:2364]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytokine receptor like factor 1
Mouse
Rat
Dog
cytokine receptor like factor 1
Horse
cytokine receptor like factor 1 [Source:HGNC Symbol;Acc:HGNC:2364]
Publication Statistics
PubMed Score 53.22
PubMed score by year
PubTator Score 103.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title