Protein Summary
May mediate the transduction of intracellular signals. This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
- ENST00000354336
- ENSP00000346300
- ENSG00000099942
- ENST00000411769
- ENSP00000396646
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.95 | ||
interacting protein | 0.94 | ||
transcription factor binding site profile | 0.88 | ||
transcription factor perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 219.98 (req: < 5)
Gene RIFs: 69 (req: <= 3)
Antibodies: 678 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 219.98 (req: >= 5)
Gene RIFs: 69 (req: > 3)
Antibodies: 678 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (258)
IFIT5
Novelty: 0.03547542
p_int: 0.983447191
p_ni: 0.016552809
Score: 0.685
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (19)
Upstream (18)
Downstream (1)
1 – 5 of 18
Pathways (74)
Reactome (20)
KEGG (18)
PathwayCommons (22)
WikiPathways (14)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Downstream signal transduction | ||||
Reactome | Erythropoietin activates RAS | ||||
Reactome | Frs2-mediated activation | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Downstream signal transduction | ||||
Erythropoietin activates RAS | ||||
Frs2-mediated activation | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (5)
Components (4)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 2 | 2 | 74.7 | |||||
1 | 1 | 1 | 30.2 | ||||||
1 | 1 | 0 | 1.1 | 21.5 | |||||
gut microbiome measurement | 1 | 1 | 2 | 15.8 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 74.7 | |||||
1 | 30.2 | ||||||
0 | 1.1 | 21.5 | |||||
gut microbiome measurement | 2 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CRK like proto-oncogene, adaptor protein | VGNC:12833 | 107970369 | |||||
Mouse | MGI:104686 | 12929 | ||||||
Rat | RGD:6493647 | 100911248 | ||||||
Dog | CRK like proto-oncogene, adaptor protein | VGNC:39619 | 608125 | |||||
Horse | CRK like proto-oncogene, adaptor protein | VGNC:16869 | 100050855 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CRK like proto-oncogene, adaptor protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | CRK like proto-oncogene, adaptor protein | |||||
Horse | CRK like proto-oncogene, adaptor protein | |||||
Publication Statistics
PubMed Score 219.98
PubMed score by year
PubTator Score 130.98
PubTator score by year
Related Publications
Text Mined References (153)
GeneRif Annotations (69)
Items per page:
0 of 0
PMID | Year | Title |
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