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Tbio
CRISP3
Cysteine-rich secretory protein 3

Protein Summary
Description
This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263045
  • ENSP00000263045
  • ENSG00000096006
  • ENST00000433368
  • ENSP00000389026

Symbol
  • Aeg2
  • CRS3
  • SGP28
  • CRISP-3
  • dJ442L6.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
small molecule perturbation
0.59
biological term
0.5
tissue
0.47
PubMedID
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.38   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.38   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
DEFA4
Tbio
Novelty:  0.04566082
Score:  0.949
Data Source:  STRINGDB
OLFM4
Tbio
Novelty:  0.01048505
Score:  0.939
Data Source:  STRINGDB
MMP8
Tchem
Family:  Enzyme
Novelty:  0.00105859
Score:  0.938
Data Source:  STRINGDB
LTF
Tbio
Novelty:  0.00114254
Score:  0.934
Data Source:  STRINGDB
TCN1
Tbio
Novelty:  0.00305315
Score:  0.933
Data Source:  STRINGDB
PGLYRP1
Tbio
Novelty:  0.00231527
Score:  0.925
Data Source:  STRINGDB
LCN2
Tbio
Family:  Enzyme
Novelty:  0.00034678
Score:  0.924
Data Source:  STRINGDB
ORM2
Tbio
Novelty:  0.00837073
Score:  0.92
Data Source:  STRINGDB
ORM1
Tbio
Novelty:  0.007451
Score:  0.918
Data Source:  STRINGDB
LYZ
Tbio
Family:  Enzyme
Novelty:  0.00151342
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
38.7
reticulocyte measurement
1
1
1
13.8
reticulocyte count
1
1
1
13.6
mean reticulocyte volume
1
1
1
12.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
38.7
reticulocyte measurement
1
13.8
reticulocyte count
1
13.6
mean reticulocyte volume
1
12.7
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cysteine rich secretory protein 3 [Source:HGNC Symbol;Acc:HGNC:16904]
Opossum
cysteine-rich secretory protein 3-like
100015721
Anole lizard
serotriflin
100557540
Xenopus
cysteine-rich secretory protein 2
XB-GENE-951048
493566
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cysteine rich secretory protein 3 [Source:HGNC Symbol;Acc:HGNC:16904]
Opossum
cysteine-rich secretory protein 3-like
Anole lizard
serotriflin
Xenopus
cysteine-rich secretory protein 2
Publication Statistics
PubMed Score 65.38
PubMed score by year
PubTator Score 39.78
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title