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Tbio
CRISP2
Cysteine-rich secretory protein 2

Protein Summary
Description
May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339139
  • ENSP00000339155
  • ENSG00000124490
  • ENST00000616725
  • ENSP00000484609
  • ENST00000618917
  • ENSP00000482890

Symbol
  • GAPDL5
  • TPX1
  • CT36
  • TPX1
  • TSP1
  • GAPDL5
  • CRISP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
protein domain
0.73
cell type or tissue
0.7
cell line
0.5
microRNA
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.18   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.18   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
TACC3
Tbio
Novelty:  0.00708723
p_int:  0.999992612
p_ni:  0.000007388
Score:  0.188
Data Source:  BioPlex,STRINGDB
CTSF
Tchem
Family:  Enzyme
Novelty:  0.01359417
p_int:  0.99320603
p_ni:  0.004237803
p_wrong:  0.002556167
Score:  0.261
Data Source:  BioPlex,STRINGDB
CNTNAP3
Tbio
Novelty:  0.22791524
p_int:  0.97685514
p_ni:  0.023143295
p_wrong:  0.000001565
Score:  0.179
Data Source:  BioPlex,STRINGDB
NLGN2
Tbio
Family:  Enzyme
Novelty:  0.01613168
p_int:  0.974050052
p_ni:  0.025941386
p_wrong:  0.000008562
Score:  0.232
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.896763269
p_ni:  0.103236731
Score:  0.159
Data Source:  BioPlex,STRINGDB
PGK2
Tbio
Family:  Kinase
Novelty:  0.00832045
Score:  0.91
Data Source:  STRINGDB
FMR1NB
Tbio
Novelty:  0.1016511
Score:  0.676
Data Source:  STRINGDB
FTHL17
Tdark
Novelty:  0.01996197
Score:  0.631
Data Source:  STRINGDB
SHPK
Tbio
Family:  Kinase
Novelty:  0.16166855
Score:  0.63
Data Source:  STRINGDB
DKKL1
Tbio
Novelty:  0.00544618
Score:  0.606
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
38.7
reticulocyte measurement
1
1
1
13.8
reticulocyte count
1
1
1
13.6
mean reticulocyte volume
1
1
1
12.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
38.7
reticulocyte measurement
1
13.8
reticulocyte count
1
13.6
mean reticulocyte volume
1
12.7
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteine rich secretory protein 2
VGNC:7171
462756
Macaque
cysteine rich secretory protein 3 [Source:HGNC Symbol;Acc:HGNC:16904]
Mouse
MGI:98815
22024
Rat
RGD:621653
360445
Dog
cysteine rich secretory protein 2
VGNC:39616
474932
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteine rich secretory protein 2
Macaque
cysteine rich secretory protein 3 [Source:HGNC Symbol;Acc:HGNC:16904]
Mouse
Rat
Dog
cysteine rich secretory protein 2
Publication Statistics
PubMed Score 56.18
PubMed score by year
PubTator Score 37.05
PubTator score by year
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Related Publications
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PMID
Year
Title