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Tclin
CRHR1
Corticotropin-releasing factor receptor 1

Protein Summary
Description
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314537
  • ENSP00000326060
  • ENSG00000120088
  • ENST00000352855
  • ENSP00000344068
  • ENST00000398285
  • ENSP00000381333
  • ENST00000577353
  • ENSP00000462016
  • ENST00000616274
  • ENSP00000480396
  • ENSG00000276191
  • ENST00000616748
  • ENSP00000478177
  • ENST00000617905
  • ENSP00000483802
  • ENST00000633723
  • ENSP00000488342

Symbol
  • CRFR
  • CRFR1
  • CRHR
  • MGC57346-CRHR1
  • CRHR1-IT1-CRHR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
co-expressed gene
1
disease
0.77
phenotype
0.77
biological term
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1135.4   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 480   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1135.4   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 480   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1285
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1285)
Protein-Protein Interactions (274)
CRH
Tbio
Novelty:  0.000147
Score:  0.999
Data Source:  Reactome,STRINGDB
UCN
Tbio
Novelty:  0.00151712
Score:  0.995
Data Source:  Reactome,STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.987
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.965
Data Source:  STRINGDB
ADCYAP1
Tbio
Family:  Enzyme
Novelty:  0.00080219
Score:  0.959
Data Source:  STRINGDB
MC2R
Tclin
Family:  GPCR
Novelty:  0.00485539
Score:  0.958
Data Source:  STRINGDB
NPSR1
Tchem
Family:  GPCR
Novelty:  0.00562139
Score:  0.956
Data Source:  STRINGDB
DRD1
Tclin
Family:  GPCR
Novelty:  0.00165886
Score:  0.956
Data Source:  STRINGDB
VIP
Tbio
Novelty:  0.00024946
Score:  0.954
Data Source:  STRINGDB
AVP
Tbio
Novelty:  0.00016475
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Class B/2 (Secretin family receptors) (R-HSA-373080)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (102)
Items per page:
1 – 5 of 102
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
6
24
13
7.6
96.8
neuroticism measurement
6
24
13
7.6
96.8
self reported educational attainment
6
6
5
4
96.8
self reported educational attainment
6
6
5
4
96.8
3
2
0
1.3
94.1
Items per page:
1 – 5 of 102
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
13
7.6
96.8
neuroticism measurement
13
7.6
96.8
self reported educational attainment
5
4
96.8
self reported educational attainment
5
4
96.8
0
1.3
94.1
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IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
corticotropin releasing hormone receptor 1
574095
Mouse
MGI:88498
12921
Rat
RGD:61276
58959
Cow
corticotropin releasing hormone receptor 1
281716
Opossum
corticotropin releasing hormone receptor 1
100024819
Species
Name
OMA
EggNOG
Inparanoid
Macaque
corticotropin releasing hormone receptor 1
Mouse
Rat
Cow
corticotropin releasing hormone receptor 1
Opossum
corticotropin releasing hormone receptor 1
Publication Statistics
PubMed Score 1135.40
PubMed score by year
Patents
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Related Publications
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PMID
Year
Title