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Tbio
CRELD2
Cysteine-rich with EGF-like domain protein 2

Protein Summary
Description
May regulate transport of alpha4-beta2 neuronal acetylcholine receptor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328268
  • ENSP00000332223
  • ENSG00000184164
  • ENST00000403427
  • ENSP00000384111
  • ENST00000404488
  • ENSP00000383938
  • ENST00000407217
  • ENSP00000386034
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.92
transcription factor perturbation
0.91
histone modification site profile
0.9
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.75   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.75   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.999333036
p_ni:  0.000666963
Data Source:  BioPlex
WNT7A
Tbio
Novelty:  0.00421662
p_int:  0.992352248
p_ni:  0.007647567
p_wrong:  1.85e-7
Score:  0.167
Data Source:  BioPlex,STRINGDB
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.974794544
p_ni:  0.025205429
p_wrong:  2.6e-8
Data Source:  BioPlex
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.939704744
p_ni:  0.06029187
p_wrong:  0.000003387
Data Source:  BioPlex
F11
Tchem
Family:  Enzyme
Novelty:  0.00169618
p_int:  0.886266509
p_ni:  0.113733476
p_wrong:  1.5e-8
Score:  0.282
Data Source:  BioPlex,STRINGDB
WISP3
Tbio
Novelty:  0.008264
p_int:  0.876495184
p_ni:  0.123504783
p_wrong:  3.3e-8
Score:  0.295
Data Source:  BioPlex,STRINGDB
FAM19A2
Tbio
Novelty:  0.28999346
p_int:  0.835202424
p_ni:  0.164795669
p_wrong:  0.000001907
Data Source:  BioPlex
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.833236408
p_ni:  0.166750824
p_wrong:  0.000012769
Data Source:  BioPlex
TMEM126A
Tbio
Novelty:  0.11759225
p_int:  0.822785551
p_ni:  0.177203079
p_wrong:  0.000011371
Data Source:  BioPlex
F7
Tchem
Family:  Enzyme
Novelty:  0.0002521
p_int:  0.803870921
p_ni:  0.174242374
p_wrong:  0.021886705
Score:  0.416
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
2
1
86.6
platelet count
1
1
1
70.5
heel bone mineral density
2
2
2
68.8
sex hormone-binding globulin measurement
4
3
6
65.6
alkaline phosphatase measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
86.6
platelet count
1
70.5
heel bone mineral density
2
68.8
sex hormone-binding globulin measurement
6
65.6
alkaline phosphatase measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteine rich with EGF like domains 2
VGNC:12832
458927
Macaque
cysteine rich with EGF like domains 2
720586
Mouse
MGI:1923987
76737
Rat
RGD:1310614
362978
Dog
cysteine rich with EGF like domains 2
VGNC:39608
100686873
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteine rich with EGF like domains 2
Macaque
cysteine rich with EGF like domains 2
Mouse
Rat
Dog
cysteine rich with EGF like domains 2
Publication Statistics
PubMed Score 14.75
PubMed score by year
PubTator Score 5.35
PubTator score by year
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Related Publications
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PMID
Year
Title