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Tbio
CRELD1
Cysteine-rich with EGF-like domain protein 1

Protein Summary
Description
This gene encodes a member of a subfamily of epidermal growth factor-related proteins. The encoded protein is characterized by a cysteine-rich with epidermal growth factor-like domain. This protein may function as a cell adhesion molecule. Mutations in this gene are the cause of atrioventricular septal defect. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326434
  • ENSP00000321856
  • ENSG00000163703
  • ENST00000383811
  • ENSP00000373322
  • ENST00000397170
  • ENSP00000380355
  • ENST00000452070
  • ENSP00000393643

Symbol
  • CIRRIN
  • AVSD2
  • CIRRIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.91
transcription factor binding site profile
0.76
tissue
0.56
cell type or tissue
0.55


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.05   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.05   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.9985387
p_ni:  0.001460822
p_wrong:  4.78e-7
Data Source:  BioPlex
CD27
Tbio
Novelty:  0.00090508
p_int:  0.986981083
p_ni:  0.012850694
p_wrong:  0.000168223
Score:  0.157
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.98160475
p_ni:  0.018216355
p_wrong:  0.000178895
Data Source:  BioPlex
CES2
Tchem
Family:  Enzyme
Novelty:  0.00177726
p_int:  0.969615371
p_ni:  0.030384627
p_wrong:  2e-9
Data Source:  BioPlex
ANKRD9
Tdark
Novelty:  0.43181793
p_int:  0.967477208
p_ni:  0.032522788
p_wrong:  4e-9
Data Source:  BioPlex
CYP26B1
Tchem
Novelty:  0.00990332
p_int:  0.946470026
p_ni:  0.053529888
p_wrong:  8.6e-8
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.901624728
p_ni:  0.011710517
p_wrong:  0.086664755
Data Source:  BioPlex
HIBADH
Tbio
Family:  Enzyme
Novelty:  0.03861647
p_int:  0.874591879
p_ni:  0.125408105
p_wrong:  1.6e-8
Data Source:  BioPlex
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.768085865
p_ni:  0.012479137
p_wrong:  0.219434997
Data Source:  BioPlex
GDF2
Tbio
Novelty:  0.00433233
Score:  0.648
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
40.6
body mass index
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
40.6
body mass index
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteine rich with EGF like domains 1
VGNC:11377
460160
Macaque
cysteine rich with EGF like domains 1
699345
Mouse
MGI:2152539
171508
Rat
RGD:1309412
312638
Dog
cysteine rich with EGF like domains 1
VGNC:39607
610107
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteine rich with EGF like domains 1
Macaque
cysteine rich with EGF like domains 1
Mouse
Rat
Dog
cysteine rich with EGF like domains 1
Publication Statistics
PubMed Score 23.05
PubMed score by year
PubTator Score 17.98
PubTator score by year
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Related Publications
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PMID
Year
Title