Tbio CRELD1 Cysteine-rich with EGF-like domain protein 1

Protein Summary

Description

This gene encodes a member of a subfamily of epidermal growth factor-related proteins. The encoded protein is characterized by a cysteine-rich with epidermal growth factor-like domain. This protein may function as a cell adhesion molecule. Mutations in this gene are the cause of atrioventricular septal defect. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q96HD1
• A8MX90
• B2RAA9
• Q6I9X5
• Q8NFT4
• Q9Y409

Gene Name

• CRELD1

Ensembl ID

• ENST00000326434
• ENSP00000321856
• ENSG00000163703
• ENST00000383811
• ENSP00000373322
• ENST00000397170
• ENSP00000380355
• ENST00000452070
• ENSP00000393643

Symbol

• CIRRIN
• AVSD2
• CIRRIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
histone modification site profile	0.91
transcription factor binding site profile	0.76
tissue	0.56
cell type or tissue	0.55

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cysteine-rich With Egf-like Domain Protein 1

Protein / Extracellular Matrix Protein / Extracellular Matrix Structural Protein / Cysteine-rich With Egf-like Domain Protein 1

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Cysteine-rich With Egf-like Domain Protein 1

Protein / Cell Adhesion Molecule / Cysteine-rich With Egf-like Domain Protein 1

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Cysteine-rich With Egf-like Domain Protein 1

Protein / Calcium-binding Protein / Annexin / Cysteine-rich With Egf-like Domain Protein 1

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Cysteine-rich With Egf-like Domain Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.95   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.95   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0