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Tbio
CREG1
Protein CREG1

Protein Summary
Description
May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R. The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370509
  • ENSP00000359540
  • ENSG00000143162

Symbol
  • CREG
  • CREG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.88
transcription factor perturbation
0.84
molecular function
0.76
histone modification site profile
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.12   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.12   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (179)
ZBED1
Tbio
Family:  TF
Novelty:  0.01645222
p_int:  0.997246013
p_ni:  0.002753987
Score:  0.221
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.94801465
p_ni:  0.051985344
p_wrong:  6e-9
Data Source:  BioPlex
AIRE
Tbio
Family:  TF; Epigenetic
Novelty:  0.00158659
p_int:  0.89321763
p_ni:  0.106778047
p_wrong:  0.000004324
Score:  0.199
Data Source:  BioPlex,STRINGDB
CTSC
Tchem
Family:  Enzyme
Novelty:  0.00119917
Score:  0.931
Data Source:  STRINGDB
C3
Tclin
Novelty:  0.00019115
Score:  0.926
Data Source:  STRINGDB
RNASET2
Tbio
Family:  Enzyme
Novelty:  0.01939252
Score:  0.921
Data Source:  STRINGDB
NPC2
Tbio
Novelty:  0.00342898
Score:  0.92
Data Source:  STRINGDB
HEXB
Tchem
Family:  Enzyme
Novelty:  0.0085045
Score:  0.915
Data Source:  STRINGDB
MAN2B1
Tchem
Family:  Enzyme
Novelty:  0.0051017
Score:  0.909
Data Source:  STRINGDB
GNS
Tbio
Family:  Enzyme
Novelty:  0.01528509
Score:  0.908
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (29)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
6
0
1.1
93.2
3
2
0
1.1
88.2
Eczema
2
1
0
1.1
76.6
childhood onset asthma
1
1
0
1.1
74.6
3
2
0
1.1
72.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
93.2
0
1.1
88.2
Eczema
0
1.1
76.6
childhood onset asthma
0
1.1
74.6
0
1.1
72.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cellular repressor of E1A stimulated genes 1
VGNC:6738
747516
Mouse
MGI:1344382
433375
Rat
RGD:1306804
289185
Dog
cellular repressor of E1A stimulated genes 1
VGNC:39605
100686738
Horse
cellular repressor of E1A stimulated genes 1
VGNC:50823
100056817
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cellular repressor of E1A stimulated genes 1
Mouse
Rat
Dog
cellular repressor of E1A stimulated genes 1
Horse
cellular repressor of E1A stimulated genes 1
Publication Statistics
PubMed Score 177.12
PubMed score by year
PubTator Score 45.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title