Tbio CREBRF CREB3 regulatory factor

Protein Summary

Description

Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.

Uniprot Accession IDs

• Q8IUR6
• B3DFH2
• B3KW49
• D3DQM2
• F5GXN3
• Q5HYG4
• Q5HYK0
• Q86YR3
• Q8IZG1

Gene Name

• CREBRF

Ensembl ID

• ENST00000296953
• ENSP00000296953
• ENSG00000164463
• ENST00000520420
• ENSP00000428290
• ENST00000522692
• ENSP00000431107

Symbol

• C5orf41
• LRF
• C5orf41

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.92
kinase perturbation	0.81
transcription factor binding site profile	0.77
transcription factor	0.73
tissue sample	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.26   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 26   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.26   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0