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Tchem
CREBBP
CREB-binding protein

Protein Summary
Description
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic develo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262367
  • ENSP00000262367
  • ENSG00000005339
  • ENST00000382070
  • ENSP00000371502

Symbol
  • CBP
  • CBP
  • RSTS
  • KAT3A
  • MKHK1
  • RSTS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
pathway
1
viral protein
1
virus
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 725.4   (req: < 5)
Gene RIFs: 242   (req: <= 3)
Antibodies: 595   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 725.4   (req: >= 5)
Gene RIFs: 242   (req: > 3)
Antibodies: 595   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 221
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0