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Tbio
CREB5
Cyclic AMP-responsive element-binding protein 5

Protein Summary
Description
Binds to the cAMP response element and activates transcription. The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357727
  • ENSP00000350359
  • ENSG00000146592
  • ENST00000396298
  • ENSP00000379592
  • ENST00000396299
  • ENSP00000379593
  • ENST00000396300
  • ENSP00000379594
  • ENST00000409603
  • ENSP00000387197

Symbol
  • CREBPA
  • CREB-5
  • CREBPA
  • CRE-BPA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
virus perturbation
0.9
kinase perturbation
0.84
transcription factor
0.81
microRNA
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.89   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.89   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0