Tbio CREB3L4 Cyclic AMP-responsive element-binding protein 3-like protein 4

Protein Summary

Description

Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q8TEY5
• D3DV62
• Q5T4L0
• Q86YW6
• cAMP-responsive element-binding protein 3-like protein 4

Gene Name

• CREB3L4

Ensembl ID

• ENST00000271889
• ENSP00000271889
• ENSG00000143578
• ENST00000368600
• ENSP00000357589
• ENST00000368603
• ENSP00000357592
• ENST00000368607
• ENSP00000357596

Symbol

• AIBZIP
• CREB4
• JAL
• JAL
• hJAL
• ATCE1
• CREB3
• CREB4
• AIBZIP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.7
virus perturbation	0.68
cell type or tissue	0.67
gene perturbation	0.65
histone modification site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.74   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 241   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.74   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0