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Tdark
CRAMP1
Protein cramped-like

Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.61   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.61   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
GON4L
Tbio
Novelty:  0.06166736
p_int:  0.999999952
p_ni:  4.8e-8
Score:  0.854
Data Source:  BioPlex,STRINGDB
MAGEE1
Tbio
Novelty:  0.10759081
p_int:  0.999998913
p_ni:  0.000001087
Score:  0.163
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999996873
p_ni:  0.000003127
Data Source:  BioPlex
NPAT
Tbio
Novelty:  0.01063979
p_int:  0.999994322
p_ni:  0.000005678
Score:  0.571
Data Source:  BioPlex,STRINGDB
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.999992772
p_ni:  0.000007223
p_wrong:  5e-9
Data Source:  BioPlex
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999991664
p_ni:  0.000008332
p_wrong:  4e-9
Data Source:  BioPlex
PPP4R3B
Tbio
Family:  Enzyme
Novelty:  0.0185504
p_int:  0.999891932
p_ni:  0.000108068
Score:  0.719
Data Source:  BioPlex,STRINGDB
SS18L2
Tdark
Novelty:  1.37000973
p_int:  0.999716972
p_ni:  0.000036304
p_wrong:  0.000246724
Score:  0.84
Data Source:  BioPlex,STRINGDB
USP20
Tbio
Family:  Enzyme
Novelty:  0.06647037
p_int:  0.999211361
p_ni:  0.000632585
p_wrong:  0.000156054
Score:  0.208
Data Source:  BioPlex,STRINGDB
PPP4R3A
Tbio
Family:  Enzyme
Novelty:  0.04234592
p_int:  0.997379114
p_ni:  0.002620876
p_wrong:  1.1e-8
Score:  0.571
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
6
6
96.4
1
1
0
14
40.7
maculopapular eruption
1
1
0
14
40.7
response to lamotrigine
1
1
0
14
40.7
snoring measurement
2
2
1
1.1
39.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
6
96.4
0
14
40.7
maculopapular eruption
0
14
40.7
response to lamotrigine
0
14
40.7
snoring measurement
1
1.1
39.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cramped chromatin regulator homolog 1
VGNC:51564
453823
Macaque
cramped chromatin regulator homolog 1
722473
Mouse
MGI:1930190
57354
Rat
RGD:1311948
287127
Dog
cramped chromatin regulator homolog 1
VGNC:54014
100856642
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cramped chromatin regulator homolog 1
Macaque
cramped chromatin regulator homolog 1
Mouse
Rat
Dog
cramped chromatin regulator homolog 1
Publication Statistics
PubMed Score 3.61
PubMed score by year
PubTator Score 3.70
PubTator score by year
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Related Publications
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PMID
Year
Title