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Tbio
CRACR2B
EF-hand calcium-binding domain-containing protein 4A

Protein Summary
Description
Plays a role in store-operated Ca(2+) entry (SOCE).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000450448
  • ENSP00000409256
  • ENSG00000177685
  • ENST00000525077
  • ENSP00000435299
  • ENST00000528542
  • ENSP00000432334

Symbol
  • EFCAB4A
  • EFCAB4A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
transcription factor perturbation
0.54
tissue
0.51
tissue sample
0.5
small molecule perturbation
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.61   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.61   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
CARD19
Tbio
Family:  Enzyme
Novelty:  0.18215136
p_int:  0.997881111
p_ni:  0.000169173
p_wrong:  0.001949716
Score:  0.455
Data Source:  BioPlex,STRINGDB
TIMM29
Tdark
Novelty:  0.51321672
p_int:  0.862241282
p_ni:  0.137758372
p_wrong:  3.46e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
MAN1A2
Tbio
Family:  Enzyme
Novelty:  0.15637608
Score:  0.689
Data Source:  STRINGDB
LIAT1
Tdark
Novelty:  0.7167986
Score:  0.584
Data Source:  STRINGDB
PADI1
Tchem
Family:  Enzyme
Novelty:  0.01388854
Score:  0.565
Data Source:  STRINGDB
GNPTAB
Tbio
Family:  Enzyme
Novelty:  0.00336101
Score:  0.561
Data Source:  STRINGDB
CDH8
Tbio
Novelty:  0.04055999
Score:  0.559
Data Source:  STRINGDB
S100A3
Tbio
Novelty:  0.03024004
Score:  0.541
Data Source:  STRINGDB
PCDHAC1
Tdark
Novelty:  0.3734734
Score:  0.537
Data Source:  STRINGDB
CDH23
Tbio
Novelty:  0.00588227
Score:  0.504
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Vitamin D Receptor Pathway
Name
Explore in Pharos
Explore in Source
Vitamin D Receptor Pathway
Vitamin D Receptor Pathway
Vitamin D Receptor Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
5
6
91.5
mean platelet volume
2
2
2
89.4
intraocular pressure measurement
2
3
3
89
waist-hip ratio
4
6
9
86.9
2
2
1
6.6
82.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
91.5
mean platelet volume
2
89.4
intraocular pressure measurement
3
89
waist-hip ratio
9
86.9
1
6.6
82.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
calcium release activated channel regulator 2B
700951
Mouse
MGI:2446129
213573
Dog
calcium release activated channel regulator 2B
VGNC:39590
611409
Horse
calcium release activated channel regulator 2B
VGNC:16848
100055181
Cow
calcium release activated channel regulator 2B [Source:HGNC Symbol;Acc:HGNC:28703]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
calcium release activated channel regulator 2B
Mouse
Dog
calcium release activated channel regulator 2B
Horse
calcium release activated channel regulator 2B
Cow
calcium release activated channel regulator 2B [Source:HGNC Symbol;Acc:HGNC:28703]
Publication Statistics
PubMed Score 0.61
PubMed score by year
PubTator Score 0.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title