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Tchem
CRACR2A
EF-hand calcium-binding domain-containing protein 4B

Protein Summary
Description
Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252322
  • ENSP00000252322
  • ENSG00000130038
  • ENST00000440314
  • ENSP00000409382

Symbol
  • EFCAB4B
  • EFCAB4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
histone modification site profile
0.73
cellular component
0.68
phenotype
0.61
disease
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.89   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.89   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 56
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (96)
IZUMO1
Tbio
Novelty:  0.01839953
p_int:  0.999970795
p_ni:  0.000029205
Score:  0.188
Data Source:  BioPlex,STRINGDB
CLUAP1
Tbio
Novelty:  0.08002286
p_int:  0.999824181
p_ni:  0.000175819
Score:  0.46
Data Source:  BioPlex,STRINGDB
MCPH1
Tbio
Novelty:  0.00881376
p_int:  0.793967214
p_ni:  0.000002734
p_wrong:  0.206030052
Score:  0.685
Data Source:  BioPlex,STRINGDB
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.784251692
p_ni:  0.21563653
p_wrong:  0.000111778
Score:  0.224
Data Source:  BioPlex,STRINGDB
FRK
Tchem
Family:  Kinase
Novelty:  0.00715757
Score:  0.907
Data Source:  STRINGDB
CEP290
Tbio
Novelty:  0.00526375
Score:  0.906
Data Source:  STRINGDB
CNN2
Tbio
Novelty:  0.02486182
Score:  0.902
Data Source:  STRINGDB
HPSE
Tchem
Family:  Enzyme
Novelty:  0.00162921
Score:  0.902
Data Source:  STRINGDB
RAB27A
Tchem
Family:  Enzyme
Novelty:  0.00369416
Score:  0.902
Data Source:  STRINGDB
CFP
Tbio
Novelty:  0.00063251
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
3.7
49.4
gut microbiome measurement
1
1
1
39.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3.7
49.4
gut microbiome measurement
1
39.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium release activated channel regulator 2A
VGNC:12903
746997
Mouse
MGI:2685919
381812
Dog
calcium release activated channel regulator 2A
VGNC:39589
486739
Zebrafish
ZDB-GENE-041210-94
564347
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium release activated channel regulator 2A
Mouse
Dog
calcium release activated channel regulator 2A
Zebrafish
Publication Statistics
PubMed Score 11.89
PubMed score by year
PubTator Score 5.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title