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Tbio
CPZ
Carboxypeptidase Z

Protein Summary
Description
Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing. This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315782
  • ENSP00000315074
  • ENSG00000109625
  • ENST00000360986
  • ENSP00000354255
  • ENST00000382480
  • ENSP00000371920
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
cell type or tissue
0.72
PubMedID
0.66
protein domain
0.58
molecular function
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 984.3   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 984.3   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
L3HYPDH
Tdark
Family:  Enzyme
Novelty:  0.35456591
p_int:  0.999428964
p_ni:  0.000571036
Score:  0.282
Data Source:  BioPlex,STRINGDB
BAG1
Tbio
Novelty:  0.00285515
p_int:  0.946968472
p_ni:  0.048471215
p_wrong:  0.004560312
Score:  0.28
Data Source:  BioPlex,STRINGDB
AFF1
Tbio
Family:  TF
Novelty:  0.00094358
Score:  0.86
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.716
Data Source:  STRINGDB
PCSK2
Tchem
Family:  Enzyme
Novelty:  0.00611421
Score:  0.71
Data Source:  STRINGDB
GSN
Tbio
Novelty:  0.00060852
Score:  0.705
Data Source:  STRINGDB
RTN4
Tbio
Novelty:  0.00080371
Score:  0.685
Data Source:  STRINGDB
PLXNA2
Tbio
Novelty:  0.01765957
Score:  0.663
Data Source:  STRINGDB
PLK4
Tchem
Family:  Kinase
Novelty:  0.00265851
Score:  0.65
Data Source:  STRINGDB
TNPO3
Tbio
Novelty:  0.01709028
Score:  0.624
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
76
body fat distribution
1
1
2
57.3
1
1
0
1.3
55.2
1
1
0
1.3
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
76
body fat distribution
2
57.3
0
1.3
55.2
0
1.3
11.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase Z
471140
Mouse
MGI:88487
242939
Rat
RGD:620496
83575
Dog
carboxypeptidase Z
VGNC:39587
488792
Horse
carboxypeptidase Z
VGNC:51163
100070438
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase Z
Mouse
Rat
Dog
carboxypeptidase Z
Horse
carboxypeptidase Z
Publication Statistics
PubMed Score 984.30
PubMed score by year
PubTator Score 25.72
PubTator score by year
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Related Publications
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PMID
Year
Title