Protein Summary
Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing. This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000315782
- ENSP00000315074
- ENSG00000109625
- ENST00000360986
- ENSP00000354255
- ENST00000382480
- ENSP00000371920
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.81 | ||
cell type or tissue | 0.72 | ||
PubMedID | 0.66 | ||
protein domain | 0.58 | ||
molecular function | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 984.3 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 55 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 984.3 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 55 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (34)
L3HYPDH
Family: Enzyme
Novelty: 0.35456591
p_int: 0.999428964
p_ni: 0.000571036
Score: 0.282
Data Source: BioPlex,STRINGDB
BAG1
Novelty: 0.00285515
p_int: 0.946968472
p_ni: 0.048471215
p_wrong: 0.004560312
Score: 0.28
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (1)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 76 | |||||
body fat distribution | 1 | 1 | 2 | 57.3 | |||||
1 | 1 | 0 | 1.3 | 55.2 | |||||
1 | 1 | 0 | 1.3 | 11.6 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 76 | |||||
body fat distribution | 2 | 57.3 | |||||
0 | 1.3 | 55.2 | |||||
0 | 1.3 | 11.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | carboxypeptidase Z | 471140 | ||||||
Mouse | MGI:88487 | 242939 | ||||||
Rat | RGD:620496 | 83575 | ||||||
Dog | carboxypeptidase Z | VGNC:39587 | 488792 | |||||
Horse | carboxypeptidase Z | VGNC:51163 | 100070438 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | carboxypeptidase Z | |||||
Mouse | ||||||
Rat | ||||||
Dog | carboxypeptidase Z | |||||
Horse | carboxypeptidase Z | |||||
Publication Statistics
PubMed Score 984.30
PubMed score by year
PubTator Score 25.72
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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