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Tbio
CPVL
Probable serine carboxypeptidase CPVL

Protein Summary
Description
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265394
  • ENSP00000265394
  • ENSG00000106066
  • ENST00000396276
  • ENSP00000379572
  • ENST00000409850
  • ENSP00000387164

Symbol
  • VLP
  • HVLP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.79
gene perturbation
0.75
tissue sample
0.69
trait
0.61
disease
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.1   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.1   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
CYB5R3
Tbio
Family:  Enzyme
Novelty:  0.00774258
p_int:  0.997399763
p_ni:  0.002590112
p_wrong:  0.000010125
Score:  0.156
Data Source:  BioPlex,STRINGDB
NAT14
Tbio
Family:  Enzyme
Novelty:  0.08842982
p_int:  0.976177053
p_ni:  0.023822947
Score:  0.177
Data Source:  BioPlex,STRINGDB
LETMD1
Tbio
Novelty:  0.02790517
p_int:  0.892721945
p_ni:  0.107278055
Score:  0.19
Data Source:  BioPlex,STRINGDB
NEXN
Tbio
Novelty:  0.00745011
p_int:  0.890899047
p_ni:  0.109100952
Score:  0.161
Data Source:  BioPlex,STRINGDB
ABHD12
Tchem
Family:  Enzyme
Novelty:  0.02587535
p_int:  0.85786761
p_ni:  0.14213239
Score:  0.371
Data Source:  BioPlex,STRINGDB
NT5C3A
Tbio
Family:  Enzyme
Novelty:  0.01939545
p_int:  0.802179405
p_ni:  0.197815466
p_wrong:  0.000005129
Score:  0.219
Data Source:  BioPlex,STRINGDB
OCIAD1
Tbio
Novelty:  0.05701069
p_int:  0.797648522
p_ni:  0.20235147
p_wrong:  8e-9
Score:  0.213
Data Source:  BioPlex,STRINGDB
TMEM177
Tdark
Novelty:  2.94456186
p_int:  0.796971461
p_ni:  0.196472483
p_wrong:  0.006556056
Score:  0.622
Data Source:  BioPlex,STRINGDB
SARNP
Tbio
Novelty:  0.00987312
p_int:  0.768449448
p_ni:  0.231550552
Score:  0.185
Data Source:  BioPlex,STRINGDB
ERLEC1
Tbio
Novelty:  0.01243855
Score:  0.794
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.8
86.8
2
1
1
1.3
82
keratinocyte carcinoma
1
1
0
1.3
74.9
brain measurement
1
1
0
7.5
49.3
non-melanoma skin carcinoma
1
1
0
1.4
41.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
86.8
1
1.3
82
keratinocyte carcinoma
0
1.3
74.9
brain measurement
0
7.5
49.3
non-melanoma skin carcinoma
0
1.4
41.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase, vitellogenic like
VGNC:7370
463319
Macaque
carboxypeptidase, vitellogenic like
697111
Mouse
MGI:1918537
71287
Rat
RGD:1563609
502774
Dog
carboxypeptidase, vitellogenic like
VGNC:39584
611483
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase, vitellogenic like
Macaque
carboxypeptidase, vitellogenic like
Mouse
Rat
Dog
carboxypeptidase, vitellogenic like
Publication Statistics
PubMed Score 20.10
PubMed score by year
PubTator Score 14.39
PubTator score by year
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Related Publications
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PMID
Year
Title