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Tbio
CPTP
Ceramide-1-phosphate transfer protein

Protein Summary
Description
Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (PubMed:28011644). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:29164996).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343938
  • ENSP00000343890
  • ENSG00000224051

Symbol
  • GLTPD1
  • GLTPD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
small molecule perturbation
0.71
molecular function
0.63
tissue sample
0.63
metabolite
0.62


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.22   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.22   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (15)
ACP4
Tbio
Family:  Enzyme
Novelty:  0.01397537
Score:  0.708
Data Source:  STRINGDB
CERK
Tchem
Family:  Kinase
Novelty:  0.0103948
Score:  0.643
Data Source:  STRINGDB
GLTP
Tbio
Novelty:  0.01044466
Score:  0.619
Data Source:  STRINGDB
ACER1
Tbio
Family:  Enzyme
Novelty:  0.05571844
Score:  0.547
Data Source:  STRINGDB
CKAP4
Tbio
Novelty:  0.02104039
Score:  0.494
Data Source:  STRINGDB
DFFB
Tbio
Novelty:  0.00475349
Score:  0.475
Data Source:  STRINGDB
METTL27
Tdark
Novelty:  0.34658724
Score:  0.464
Data Source:  STRINGDB
PIK3IP1
Tbio
Family:  Enzyme
Novelty:  0.07364653
Score:  0.459
Data Source:  STRINGDB
RERE
Tbio
Family:  TF
Novelty:  0.03065098
Score:  0.458
Data Source:  STRINGDB
RNF225
Tdark
Score:  0.453
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Glycosphingolipid metabolism (R-HSA-1660662)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
56.2
intraocular pressure measurement
1
2
2
52.7
1
1
0
1.1
35
heel bone mineral density
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
56.2
intraocular pressure measurement
2
52.7
0
1.1
35
heel bone mineral density
1
6.7
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ceramide-1-phosphate transfer protein
700679
Mouse
MGI:1933107
79554
Rat
RGD:1359656
313771
Dog
ceramide-1-phosphate transfer protein
VGNC:39583
100855790
Horse
ceramide-1-phosphate transfer protein
VGNC:16843
100061495
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ceramide-1-phosphate transfer protein
Mouse
Rat
Dog
ceramide-1-phosphate transfer protein
Horse
ceramide-1-phosphate transfer protein
Publication Statistics
PubMed Score 49.22
PubMed score by year
PubTator Score 13.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title