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Tchem
CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

Protein Summary
Description
The protein encoded by this gene is a nuclear protein which is transported to the mitochondrial inner membrane. Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371486
  • ENSP00000360541
  • ENSG00000157184

Symbol
  • CPT1
  • CPT1
  • IIAE4
  • CPTASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
phenotype
0.77
cellular component
0.72
interacting protein
0.72
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.35   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 454   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.35   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 454   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 35
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (187)
FAHD1
Tbio
Family:  Enzyme
Novelty:  0.07873941
p_int:  0.998970733
p_ni:  0.001029267
Score:  0.245
Data Source:  BioPlex,STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
p_int:  0.989726045
p_ni:  0.010273955
Score:  0.331
Data Source:  BioPlex,STRINGDB
P63092
Tbio
Novelty:  0.00284739
p_int:  0.988176583
p_ni:  0.011823417
Score:  0.175
Data Source:  BioPlex,STRINGDB
NDUFA13
Tclin
Family:  Enzyme
Novelty:  0.01605077
p_int:  0.987665933
p_ni:  0.012334067
Score:  0.362
Data Source:  BioPlex,STRINGDB
MCUR1
Tbio
Novelty:  0.06505266
p_int:  0.983910359
p_ni:  0.016089641
Score:  0.395
Data Source:  BioPlex,STRINGDB
GPT2
Tbio
Family:  Enzyme
Novelty:  0.00478585
p_int:  0.982424769
p_ni:  0.017575231
Score:  0.468
Data Source:  BioPlex,STRINGDB
MRM3
Tbio
Family:  Enzyme
Novelty:  0.06515109
p_int:  0.91893577
p_ni:  0.08106423
Score:  0.151
Data Source:  BioPlex,STRINGDB
TMEM70
Tbio
Novelty:  0.03111438
p_int:  0.892633613
p_ni:  0.107366386
p_wrong:  1e-9
Score:  0.21
Data Source:  BioPlex,STRINGDB
ARHGEF26
Tbio
Novelty:  0.09349583
p_int:  0.885866492
p_ni:  0.114133505
p_wrong:  3e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
MTRF1
Tbio
Family:  Enzyme
Novelty:  0.11037387
p_int:  0.822472898
p_ni:  0.1775271
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Import of palmitoyl-CoA into the mitochondrial matrix
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Import of palmitoyl-CoA into the mitochondrial matrix
Metabolism
Metabolism of lipids
PPARA activates gene expression
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
78.6
metabolite measurement
1
2
2
73.3
self reported educational attainment
1
1
1
44.2
urinary metabolite measurement
1
1
1
42.3
feeling emotionally hurt measurement
1
1
0
5.8
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
78.6
metabolite measurement
2
73.3
self reported educational attainment
1
44.2
urinary metabolite measurement
1
42.3
feeling emotionally hurt measurement
0
5.8
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carnitine palmitoyltransferase 2
VGNC:1223
737945
Macaque
carnitine palmitoyltransferase 2
714150
Mouse
MGI:109176
12896
Rat
RGD:2398
25413
Dog
carnitine palmitoyltransferase 2
VGNC:39582
489585
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carnitine palmitoyltransferase 2
Macaque
carnitine palmitoyltransferase 2
Mouse
Rat
Dog
carnitine palmitoyltransferase 2
Publication Statistics
PubMed Score 296.35
PubMed score by year
PubTator Score 379.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title