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Tbio
CPSF6
Cleavage and polyadenylation specificity factor subunit 6

Protein Summary
Description
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localize ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266679
  • ENSP00000266679
  • ENSG00000111605
  • ENST00000435070
  • ENSP00000391774

Symbol
  • CFIM68
  • CFIM
  • CFIM68
  • CFIM72
  • HPBRII-4
  • HPBRII-7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.82
transcription factor perturbation
0.8
interacting protein
0.76
hub protein
0.75
transcription factor
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.75   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.75   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (208)
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999950415
p_ni:  0.000049585
Score:  0.357
Data Source:  BioPlex,STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.99989033
p_ni:  0.00010967
Data Source:  BioPlex
CPSF7
Tbio
Novelty:  0.13068955
p_int:  0.999429315
p_ni:  0.000570685
Score:  0.985
Data Source:  BioPlex,STRINGDB
ITCH
Tbio
Family:  Enzyme
Novelty:  0.00681861
p_int:  0.928059773
p_ni:  0.071940225
p_wrong:  3e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
WWP1
Tbio
Family:  Enzyme
Novelty:  0.01407874
p_int:  0.915371818
p_ni:  0.084628182
Score:  0.268
Data Source:  BioPlex,STRINGDB
RBBP6
Tbio
Family:  Enzyme
Novelty:  0.03147368
p_int:  0.886939934
p_ni:  0.113060066
Score:  0.313
Data Source:  BioPlex,STRINGDB
WWP2
Tbio
Family:  Enzyme
Novelty:  0.01935799
p_int:  0.839679222
p_ni:  0.160320778
Score:  0.225
Data Source:  BioPlex,STRINGDB
NUDT21
Tbio
Novelty:  0.02174736
p_int:  0.759109056
p_ni:  0.240890944
Score:  0.999
Data Source:  BioPlex,STRINGDB
CSTF2
Tbio
Novelty:  0.01389909
Score:  0.986
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.983
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FGFR1 mutant receptor activation
Reactome
Signaling by FGFR in disease
Reactome
Signaling by FGFR1 in disease
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
FGFR1 mutant receptor activation
Signaling by FGFR in disease
Signaling by FGFR1 in disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
88
monocyte percentage of leukocytes
2
1
2
87.7
Oral ulcer
1
1
0
1.1
80.6
granulocyte percentage of myeloid white cells
1
1
1
80.4
leukocyte count
1
2
2
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
88
monocyte percentage of leukocytes
2
87.7
Oral ulcer
0
1.1
80.6
granulocyte percentage of myeloid white cells
1
80.4
leukocyte count
2
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cleavage and polyadenylation specific factor 6
VGNC:5347
452068
Macaque
cleavage and polyadenylation specific factor 6
718331
Mouse
MGI:1913948
432508
Rat
RGD:1304640
299811
Dog
cleavage and polyadenylation specific factor 6
VGNC:39577
474441
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cleavage and polyadenylation specific factor 6
Macaque
cleavage and polyadenylation specific factor 6
Mouse
Rat
Dog
cleavage and polyadenylation specific factor 6
Publication Statistics
PubMed Score 94.75
PubMed score by year
PubTator Score 36.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title