Tdark CPSF4L Putative cleavage and polyadenylation specificity factor subunit 4-like protein

Protein Summary

Uniprot Accession IDs

• A6NMK7
• A8MU95
• B2RXI9

Gene Name

• CPSF4L

Ensembl ID

• ENST00000344935
• ENSP00000343900
• ENSG00000187959

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.9
PubMedID	0.57
virus perturbation	0.55
transcription factor binding site profile	0.54
tissue	0.45

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endoribonuclease / Putative Cleavage And Polyadenylation Specificity Factor Subunit 4-like Protein

Protein / Nucleic Acid Binding / Rna Binding Protein / Endoribonuclease / Putative Cleavage And Polyadenylation Specificity Factor Subunit 4-like Protein

DTO Classes

Protein / Enzyme / Nuclease / Endoribonuclease / Putative Cleavage And Polyadenylation Specificity Factor Subunit 4-like Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.28   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.28   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (40)

Explore Interacting Targets

1 – 10 of 40

• See Interactions on String-DB

CCNG1

Tbio

Novelty:  0.00838635

p_int:  0.999991261

p_ni:  7.2e-8

p_wrong:  0.000008667

Score:  0.218

Data Source:  BioPlex,STRINGDB

WDR33

Tbio

Novelty:  0.09221439

p_int:  0.999963858

p_ni:  0.000036142

Score:  0.858

Data Source:  BioPlex,STRINGDB

BANP

Tbio

Novelty:  0.02145545

p_int:  0.997940961

p_ni:  0.00205901

p_wrong:  2.9e-8

Score:  0.222

Data Source:  BioPlex,STRINGDB

CCNH

Tbio

Novelty:  0.00693072

p_int:  0.984199103

p_ni:  0.015745044

p_wrong:  0.000055853

Score:  0.265

Data Source:  BioPlex,STRINGDB

FIP1L1

Tbio

Novelty:  0.00520044

p_int:  0.926602137

p_ni:  0.073397863

Score:  0.957

Data Source:  BioPlex,STRINGDB

AP2A2

Tbio

Novelty:  0.08851191

p_int:  0.894896418

p_ni:  0.105103582

Score:  0.18

Data Source:  BioPlex,STRINGDB

CPSF3

Tchem

Novelty:  0.01880576

p_int:  0.85597115

p_ni:  0.14402885

Score:  0.891

Data Source:  BioPlex,STRINGDB

CPSF2

Tbio

Novelty:  0.0510853

Score:  0.915

Data Source:  STRINGDB

NUDT21

Tbio

Novelty:  0.02174736

Score:  0.839

Data Source:  STRINGDB

CSTF3

Tbio

Novelty:  0.05260909

Score:  0.829

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (2)

Components (1)

Processes (1)

Find Similar Targets

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1 – 2 of 2

GO Term	Evidence	Assigned by
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
RNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	3	2	3		79.2
mean reticulocyte volume	EFO_0010701	1	1	1		74.6
mean corpuscular volume	EFO_0004526	1	1	1		71.9
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		64.9
reticulocyte count	EFO_0007986	2	2	2		57.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	3		79.2
mean reticulocyte volume	EFO_0010701	1		74.6
mean corpuscular volume	EFO_0004526	1		71.9
mean corpuscular hemoglobin concentration	EFO_0004528	1		64.9
reticulocyte count	EFO_0007986	2		57.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Metal-binding
Reference proteome
Repeat
RNA-binding
Zinc
Zinc-finger

GWAS Trait Find Similar Targets

No Header	No Header
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean reticulocyte volume
red blood cell distribution width
reticulocyte count

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cleavage and polyadenylation specific factor 4 like	VGNC:12055	744631
Macaque	cleavage and polyadenylation specific factor 4 like [Source:HGNC Symbol;Acc:HGNC:33632]
Mouse	cleavage and polyadenylation specific factor 4-like	MGI:1277182	52670
Horse	cleavage and polyadenylation specific factor 4 like	VGNC:51474	100061214
Opossum	cleavage and polyadenylation specific factor 4 like [Source:HGNC Symbol;Acc:HGNC:33632]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cleavage and polyadenylation specific factor 4 like
Macaque	cleavage and polyadenylation specific factor 4 like [Source:HGNC Symbol;Acc:HGNC:33632]
Mouse	cleavage and polyadenylation specific factor 4-like
Horse	cleavage and polyadenylation specific factor 4 like
Opossum	cleavage and polyadenylation specific factor 4 like [Source:HGNC Symbol;Acc:HGNC:33632]

Publication Statistics

PubMed Score 0.28

PubMed score by year

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PubTator Score 0.08

PubTator score by year

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Related Publications

Text Mined References (4)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title