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Tbio
CPSF4
Cleavage and polyadenylation specificity factor subunit 4

Protein Summary
Description
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292476
  • ENSP00000292476
  • ENSG00000160917
  • ENST00000436336
  • ENSP00000395311

Symbol
  • CPSF30
  • NAR
  • NEB1
  • NAR
  • NEB1
  • NEB-1
  • CPSF30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.97
kinase perturbation
0.96
histone modification site profile
0.87
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 638.78   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 638.78   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (299)
SMYD2
Tchem
Family:  Epigenetic
Novelty:  0.0192516
p_int:  0.999999973
p_ni:  2.6e-8
p_wrong:  1e-9
Score:  0.217
Data Source:  BioPlex,STRINGDB
WDR33
Tbio
Novelty:  0.09221439
p_int:  0.999999918
p_ni:  7.9e-8
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.999999891
p_ni:  1.09e-7
p_wrong:  1e-9
Score:  0.33
Data Source:  BioPlex,STRINGDB
KLK6
Tchem
Family:  Enzyme
Novelty:  0.00488956
p_int:  0.999974435
p_ni:  0.000025565
Score:  0.19
Data Source:  BioPlex,STRINGDB
SYMPK
Tbio
Novelty:  0.01773552
p_int:  0.999965065
p_ni:  0.000034933
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
FIP1L1
Tbio
Novelty:  0.00520044
p_int:  0.999943125
p_ni:  0.000056875
Score:  0.999
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999849735
p_ni:  0.000042983
p_wrong:  0.000107282
Data Source:  BioPlex
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.999185911
p_ni:  0.000814045
p_wrong:  4.4e-8
Score:  0.265
Data Source:  BioPlex,STRINGDB
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.998811423
p_ni:  0.001188568
p_wrong:  9e-9
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.998623943
p_ni:  0.001372156
p_wrong:  0.000003901
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Host Interactions with Influenza Factors
Reactome
Infectious disease
Reactome
Influenza Infection
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Host Interactions with Influenza Factors
Infectious disease
Influenza Infection
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
2
4
6
98.7
serum metabolite measurement
1
3
3
95.8
blood metabolite measurement
1
2
3
91.6
dehydroepiandrosterone sulphate measurement
1
5
10
91.5
alcohol consumption measurement
4
3
4
87.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
6
98.7
serum metabolite measurement
3
95.8
blood metabolite measurement
3
91.6
dehydroepiandrosterone sulphate measurement
10
91.5
alcohol consumption measurement
4
87.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cleavage and polyadenylation specific factor 4
VGNC:4320
463572
Macaque
cleavage and polyadenylation specific factor 4
708119
Mouse
MGI:1861602
54188
Dog
cleavage and polyadenylation specific factor 4
VGNC:39576
489859
Horse
cleavage and polyadenylation specific factor 4
VGNC:16836
100059364
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cleavage and polyadenylation specific factor 4
Macaque
cleavage and polyadenylation specific factor 4
Mouse
Dog
cleavage and polyadenylation specific factor 4
Horse
cleavage and polyadenylation specific factor 4
Publication Statistics
PubMed Score 638.78
PubMed score by year
PubTator Score 174.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title