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Tchem
CPSF3
Cleavage and polyadenylation specificity factor subunit 3

Protein Summary
Description
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete remova ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238112
  • ENSP00000238112
  • ENSG00000119203

Symbol
  • CPSF73
  • CPSF73
  • CPSF-73
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
interacting protein
0.89
kinase perturbation
0.88
histone modification site profile
0.87
transcription factor perturbation
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.24   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.24   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (316)
CPSF4
Tbio
Novelty:  0.00206207
p_int:  0.972370416
p_ni:  0.027629584
Score:  0.997
Data Source:  BioPlex,STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.872904945
p_ni:  0.127095055
Data Source:  BioPlex
LMO1
Tbio
Novelty:  0.01670419
p_int:  0.858341422
p_ni:  0.141658578
Data Source:  BioPlex
CPSF4L
Tdark
Novelty:  4.27116708
p_int:  0.85597115
p_ni:  0.14402885
Score:  0.891
Data Source:  BioPlex,STRINGDB
UBE3D
Tbio
Family:  Enzyme
Novelty:  0.44919491
p_int:  0.813945525
p_ni:  0.186054475
Score:  0.214
Data Source:  BioPlex,STRINGDB
FIP1L1
Tbio
Novelty:  0.00520044
Score:  0.999
Data Source:  STRINGDB
CPSF1
Tbio
Novelty:  0.04396897
Score:  0.999
Data Source:  STRINGDB
WDR33
Tbio
Novelty:  0.09221439
Score:  0.999
Data Source:  STRINGDB
CPSF2
Tbio
Novelty:  0.0510853
Score:  0.999
Data Source:  STRINGDB
SYMPK
Tbio
Novelty:  0.01773552
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
3
3
90.3
tumor necrosis factor receptor 1 measurement
1
1
1
59.1
BMI-adjusted waist-hip ratio
1
1
1
55.3
parental genotype effect measurement
1
1
1
44.6
appendicular lean mass
1
1
1
18.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
90.3
tumor necrosis factor receptor 1 measurement
1
59.1
BMI-adjusted waist-hip ratio
1
55.3
parental genotype effect measurement
1
44.6
appendicular lean mass
1
18.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cleavage and polyadenylation specific factor 3
VGNC:214
459017
Mouse
MGI:1859328
54451
Rat
RGD:1305767
298916
Dog
cleavage and polyadenylation specific factor 3
VGNC:39575
100856414
Horse
cleavage and polyadenylation specific factor 3
VGNC:16835
100072510
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cleavage and polyadenylation specific factor 3
Mouse
Rat
Dog
cleavage and polyadenylation specific factor 3
Horse
cleavage and polyadenylation specific factor 3
Publication Statistics
PubMed Score 77.24
PubMed score by year
PubTator Score 20.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title