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Tbio
CPNE7
Copine-7

Protein Summary
Description
Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein may be involved in membrane trafficking. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268720
  • ENSP00000268720
  • ENSG00000178773
  • ENST00000319518
  • ENSP00000317374
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.71
small molecule perturbation
0.62
transcription factor binding site profile
0.6
histone modification site profile
0.59
PubMedID
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.54   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.54   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
GEMIN8
Tbio
Novelty:  0.19515325
p_int:  0.999865237
p_ni:  0.000134762
p_wrong:  1e-9
Data Source:  BioPlex
BAHCC1
Tdark
Novelty:  0.17231093
p_int:  0.999681428
p_ni:  0.000318561
p_wrong:  1.1e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
UBTF
Tbio
Family:  TF
Novelty:  0.00421069
p_int:  0.998518871
p_ni:  0.001481129
Score:  0.186
Data Source:  BioPlex,STRINGDB
METTL2A
Tdark
Family:  Enzyme
Novelty:  0.72443397
p_int:  0.998177104
p_ni:  0.001822896
Score:  0.179
Data Source:  BioPlex,STRINGDB
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
p_int:  0.997792048
p_ni:  0.002207951
Data Source:  BioPlex
EBF3
Tbio
Family:  TF
Novelty:  0.00311905
p_int:  0.996886618
p_ni:  0.003111898
p_wrong:  0.000001484
Score:  0.231
Data Source:  BioPlex,STRINGDB
MS4A7
Tdark
Novelty:  1.1093531
p_int:  0.995125528
p_ni:  0.004874469
p_wrong:  3e-9
Score:  0.403
Data Source:  BioPlex,STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
p_int:  0.99483118
p_ni:  0.00516882
Data Source:  BioPlex
C6orf203
Tdark
Novelty:  1.12956468
p_int:  0.989129376
p_ni:  0.010204995
p_wrong:  0.000665629
Score:  0.403
Data Source:  BioPlex,STRINGDB
CDCA4
Tbio
Novelty:  0.04549061
p_int:  0.976763431
p_ni:  0.023231434
p_wrong:  0.000005135
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
4
4
1
2.4
98.4
suntan
1
3
3
98.2
body height
2
2
2
92.6
glomerular filtration rate
6
5
5
5.5
92.5
homocysteine measurement
2
2
2
92.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
2.4
98.4
suntan
3
98.2
body height
2
92.6
glomerular filtration rate
5
5.5
92.5
homocysteine measurement
2
92.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
copine 7
713590
Mouse
MGI:2142747
102278
Rat
RGD:1307466
361433
Dog
copine 7
VGNC:39566
608773
Horse
copine 7
VGNC:16827
100052136
Species
Name
OMA
EggNOG
Inparanoid
Macaque
copine 7
Mouse
Rat
Dog
copine 7
Horse
copine 7
Publication Statistics
PubMed Score 16.54
PubMed score by year
PubTator Score 2.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title