You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CPNE6
Copine-6

Protein Summary
Description
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). This gene encodes a member of the copine family. Members of this family are calcium-dependent, phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397016
  • ENSP00000380211
  • ENSG00000100884
  • ENST00000537691
  • ENSP00000440077
  • ENST00000645359
  • ENSP00000494138
  • ENSG00000285221
  • ENST00000647071
  • ENSP00000494513
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
cell line
0.49
metabolite
0.49
molecular function
0.49
cellular component
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.15   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.15   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
CPNE4
Tbio
Novelty:  0.08077992
p_int:  0.999533156
p_wrong:  0.000466844
Score:  0.396
Data Source:  BioPlex,STRINGDB
Q9Y4C0
Tbio
Novelty:  0.00999084
Score:  0.641
Data Source:  STRINGDB
Q9HDB5
Tbio
Novelty:  0.00999084
Score:  0.641
Data Source:  STRINGDB
FLOT1
Tbio
Novelty:  0.00504569
Score:  0.635
Data Source:  STRINGDB
KALRN
Tbio
Family:  Kinase
Novelty:  0.01111401
Score:  0.608
Data Source:  STRINGDB
LIMK1
Tchem
Family:  Kinase
Novelty:  0.00349854
Score:  0.605
Data Source:  STRINGDB
GABRG1
Tclin
Family:  IC
Novelty:  0.04214561
Score:  0.595
Data Source:  STRINGDB
GFAP
Tbio
Novelty:  0.00020932
Score:  0.594
Data Source:  STRINGDB
TIAM1
Tbio
Novelty:  0.00431726
Score:  0.593
Data Source:  STRINGDB
KCNJ9
Tbio
Family:  IC
Novelty:  0.02279401
Score:  0.556
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
55.2
self reported educational attainment
1
1
1
55.2
liver disease biomarker
1
1
1
48.5
liver fat measurement
1
1
1
48.5
liver disease biomarker
1
1
1
48.5
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
55.2
self reported educational attainment
1
55.2
liver disease biomarker
1
48.5
liver fat measurement
1
48.5
liver disease biomarker
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
copine 6
100430623
Mouse
MGI:1334445
12891
Rat
RGD:1583895
691478
Dog
copine 6
VGNC:39565
608275
Horse
copine 6
VGNC:16826
100054951
Species
Name
OMA
EggNOG
Inparanoid
Macaque
copine 6
Mouse
Rat
Dog
copine 6
Horse
copine 6
Publication Statistics
PubMed Score 9.15
PubMed score by year
PubTator Score 5.50
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title