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Tbio
CPNE5
Copine-5

Protein Summary
Description
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. More variants may exist, but their full-length natures could not be determined. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244751
  • ENSP00000244751
  • ENSG00000124772
  • ENST00000393189
  • ENSP00000376885

Symbol
  • KIAA1599
  • CPN5
  • COPN5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.69
virus perturbation
0.68
kinase perturbation
0.6
cell line
0.55
transcription factor binding site profile
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.35   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.35   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
RAD54B
Tbio
Novelty:  0.02431597
p_int:  0.999999998
p_ni:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999998392
p_ni:  0.000001608
Score:  0.406
Data Source:  BioPlex,STRINGDB
RABEP2
Tbio
Family:  Enzyme
Novelty:  0.18180682
p_int:  0.999995409
p_ni:  0.000004591
Score:  0.222
Data Source:  BioPlex,STRINGDB
RABGEF1
Tbio
Novelty:  0.02830695
p_int:  0.999980347
p_ni:  0.000019653
Data Source:  BioPlex
UTRN
Tchem
Novelty:  0.0018541
p_int:  0.999863662
p_ni:  0.000136338
Score:  0.156
Data Source:  BioPlex,STRINGDB
SNTB2
Tbio
Novelty:  0.05469501
p_int:  0.999653775
p_ni:  0.000346224
p_wrong:  1e-9
Data Source:  BioPlex
MBNL3
Tbio
Novelty:  0.0492081
p_int:  0.999582295
p_ni:  0.000374283
p_wrong:  0.000043422
Score:  0.187
Data Source:  BioPlex,STRINGDB
DTNB
Tbio
Novelty:  0.0586565
p_int:  0.998669054
p_ni:  0.001330929
p_wrong:  1.7e-8
Data Source:  BioPlex
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.997683642
p_ni:  0.002316358
Score:  0.224
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.987902846
p_ni:  0.012093711
p_wrong:  0.000003442
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
2
2
16
6.5
77.7
QRS duration
2
2
1
6.5
77.4
3
2
1
1.3
74.6
neutrophil count
2
2
2
73.4
2
2
0
1.1
71.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
16
6.5
77.7
QRS duration
1
6.5
77.4
1
1.3
74.6
neutrophil count
2
73.4
0
1.1
71.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
copine 5
VGNC:7168
462651
Macaque
copine 5
719255
Mouse
MGI:2385908
240058
Rat
RGD:1308021
309650
Dog
copine 5
VGNC:39564
481768
Species
Name
OMA
EggNOG
Inparanoid
Chimp
copine 5
Macaque
copine 5
Mouse
Rat
Dog
copine 5
Publication Statistics
PubMed Score 11.35
PubMed score by year
PubTator Score 4.09
PubTator score by year
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Related Publications
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PMID
Year
Title