Tbio CPNE5 Copine-5

Protein Summary

Description

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. More variants may exist, but their full-length natures could not be determined. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• Q9HCH3
• Q7Z6C8

Gene Name

• CPNE5

Ensembl ID

• ENST00000244751
• ENSP00000244751
• ENSG00000124772
• ENST00000393189
• ENSP00000376885

Symbol

• KIAA1599
• CPN5
• COPN5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.69
virus perturbation	0.68
kinase perturbation	0.6
cell line	0.55
transcription factor binding site profile	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.35   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.35   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (46)

Explore Interacting Targets

1 – 10 of 46

• See Interactions on String-DB

RAD54B

Tbio

Novelty:  0.02431597

p_int:  0.999999998

p_ni:  2e-9

Score:  0.187

Data Source:  BioPlex,STRINGDB

NCK1

Tbio

Novelty:  0.00352084

p_int:  0.999998392

p_ni:  0.000001608

Score:  0.406

Data Source:  BioPlex,STRINGDB

RABEP2

Tbio

Family:  Enzyme

Novelty:  0.18180682

p_int:  0.999995409

p_ni:  0.000004591

Score:  0.222

Data Source:  BioPlex,STRINGDB

RABGEF1

Tbio

Novelty:  0.02830695

p_int:  0.999980347

p_ni:  0.000019653

Data Source:  BioPlex

UTRN

Tchem

Novelty:  0.0018541

p_int:  0.999863662

p_ni:  0.000136338

Score:  0.156

Data Source:  BioPlex,STRINGDB

SNTB2

Tbio

Novelty:  0.05469501

p_int:  0.999653775

p_ni:  0.000346224

p_wrong:  1e-9

Data Source:  BioPlex

MBNL3

Tbio

Novelty:  0.0492081

p_int:  0.999582295

p_ni:  0.000374283

p_wrong:  0.000043422

Score:  0.187

Data Source:  BioPlex,STRINGDB

DTNB

Tbio

Novelty:  0.0586565

p_int:  0.998669054

p_ni:  0.001330929

p_wrong:  1.7e-8

Data Source:  BioPlex

GATAD2B

Tbio

Family:  TF

Novelty:  0.056775

p_int:  0.997683642

p_ni:  0.002316358

Score:  0.224

Data Source:  BioPlex,STRINGDB

NCK2

Tbio

Novelty:  0.02220251

p_int:  0.987902846

p_ni:  0.012093711

p_wrong:  0.000003442

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (4)

Processes (2)

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1 – 1 of 1

GO Term	Evidence	Assigned by
calcium-dependent phospholipid binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (28)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 28

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
electrocardiography	EFO_0004327	2	2	16	6.5	77.7
QRS duration	EFO_0005055	2	2	1	6.5	77.4
hypertrophic cardiomyopathy	EFO_0000538	3	2	1	1.3	74.6
neutrophil count	EFO_0004833	2	2	2		73.4
atrial fibrillation	EFO_0000275	2	2	0	1.1	71.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 28

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
electrocardiography	EFO_0004327	16	6.5	77.7
QRS duration	EFO_0005055	1	6.5	77.4
hypertrophic cardiomyopathy	EFO_0000538	1	1.3	74.6
neutrophil count	EFO_0004833	2		73.4
atrial fibrillation	EFO_0000275	0	1.1	71.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell projection
Complete proteome
Differentiation
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
Abdominal Aortic Aneurysm
aspartate aminotransferase measurement
atrial fibrillation
basophil percentage of leukocytes
colorectal cancer
coronary artery disease
dilated cardiomyopathy
electrocardiography
heart failure
heart function measurement

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	copine 5	VGNC:7168	462651
Macaque	copine 5		719255
Mouse	copine V	MGI:2385908	240058
Rat	copine 5	RGD:1308021	309650
Dog	copine 5	VGNC:39564	481768

Species	Name	OMA	EggNOG	Inparanoid
Chimp	copine 5
Macaque	copine 5
Mouse	copine V
Rat	copine 5
Dog	copine 5

Publication Statistics

PubMed Score 11.35

PubMed score by year

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PubTator Score 4.09

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (3)

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10

0 of 0

PMID	Year	Title