Protein Summary
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. This gene belongs to the highly conserved copine family. It encodes a calcium-dependent, phospholipid-binding protein, which may be involved in membrane trafficking, mitogenesis and development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- ENST00000429747
- ENSP00000411904
- ENSG00000196353
- ENST00000502818
- ENSP00000421646
- ENST00000511604
- ENSP00000423811
- ENST00000512055
- ENSP00000421705
- ENST00000512332
- ENSP00000424853
- ENST00000617767
- ENSP00000478878
- CPN4
- COPN4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
cell type or tissue | 0.76 | ||
transcription factor binding site profile | 0.61 | ||
virus perturbation | 0.59 | ||
disease | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.03 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 77 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.03 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 77 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (76)
EBF3
Family: TF
Novelty: 0.00311905
p_int: 0.999833534
p_ni: 0.000166466
Score: 0.204
Data Source: BioPlex,STRINGDB
BAHCC1
Novelty: 0.17231093
p_int: 0.999825198
p_ni: 0.000174776
p_wrong: 2.6e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
CPNE6
Novelty: 0.11663358
p_int: 0.999533156
p_wrong: 0.000466844
Score: 0.396
Data Source: BioPlex,STRINGDB
RABEP2
Family: Enzyme
Novelty: 0.18180682
p_int: 0.999136981
p_ni: 0.000863019
Data Source: BioPlex
UTRN
Novelty: 0.0018541
p_int: 0.956238083
p_ni: 0.043761917
Score: 0.159
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 6 | 5 | 6 | 95.2 | |||||
body height | 1 | 2 | 2 | 87.2 | |||||
high density lipoprotein cholesterol measurement | 3 | 3 | 3 | 68.8 | |||||
waist-hip ratio | 2 | 2 | 2 | 67.5 | |||||
visceral adipose tissue measurement | 1 | 1 | 1 | 67.4 | |||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 6 | 95.2 | |||||
body height | 2 | 87.2 | |||||
high density lipoprotein cholesterol measurement | 3 | 68.8 | |||||
waist-hip ratio | 2 | 67.5 | |||||
visceral adipose tissue measurement | 1 | 67.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | copine 4 | VGNC:7048 | 460701 | |||||
Macaque | copine 4 | 719231 | ||||||
Mouse | MGI:1921270 | 74020 | ||||||
Rat | RGD:1308844 | 367160 | ||||||
Dog | copine 4 | VGNC:39563 | 485661 | |||||
Publication Statistics
PubMed Score 12.03
PubMed score by year
PubTator Score 2.00
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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