You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CPNE4
Copine-4

Protein Summary
Description
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. This gene belongs to the highly conserved copine family. It encodes a calcium-dependent, phospholipid-binding protein, which may be involved in membrane trafficking, mitogenesis and development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000429747
  • ENSP00000411904
  • ENSG00000196353
  • ENST00000502818
  • ENSP00000421646
  • ENST00000511604
  • ENSP00000423811
  • ENST00000512055
  • ENSP00000421705
  • ENST00000512332
  • ENSP00000424853
  • ENST00000617767
  • ENSP00000478878

Symbol
  • CPN4
  • COPN4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
cell type or tissue
0.76
transcription factor binding site profile
0.61
virus perturbation
0.59
disease
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.03   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.03   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.999975977
p_ni:  0.000024023
Data Source:  BioPlex
EBF3
Tbio
Family:  TF
Novelty:  0.00311905
p_int:  0.999833534
p_ni:  0.000166466
Score:  0.204
Data Source:  BioPlex,STRINGDB
BAHCC1
Tdark
Novelty:  0.17231093
p_int:  0.999825198
p_ni:  0.000174776
p_wrong:  2.6e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
CPNE6
Tbio
Novelty:  0.11663358
p_int:  0.999533156
p_wrong:  0.000466844
Score:  0.396
Data Source:  BioPlex,STRINGDB
RABEP2
Tbio
Family:  Enzyme
Novelty:  0.18180682
p_int:  0.999136981
p_ni:  0.000863019
Data Source:  BioPlex
RPS27A
Tbio
Novelty:  0.00658124
p_int:  0.996796921
p_ni:  0.003203078
Data Source:  BioPlex
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.98686067
p_ni:  0.01313933
Data Source:  BioPlex
RGPD5
Tbio
Novelty:  0.13776125
p_int:  0.96289525
p_ni:  0.03710475
Data Source:  BioPlex
GTF3C2
Tdark
Novelty:  0.1827844
p_int:  0.960307554
p_ni:  0.039692446
Data Source:  BioPlex
UTRN
Tchem
Novelty:  0.0018541
p_int:  0.956238083
p_ni:  0.043761917
Score:  0.159
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
5
6
95.2
body height
1
2
2
87.2
high density lipoprotein cholesterol measurement
3
3
3
68.8
waist-hip ratio
2
2
2
67.5
visceral adipose tissue measurement
1
1
1
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
95.2
body height
2
87.2
high density lipoprotein cholesterol measurement
3
68.8
waist-hip ratio
2
67.5
visceral adipose tissue measurement
1
67.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
copine 4
VGNC:7048
460701
Macaque
copine 4
719231
Mouse
MGI:1921270
74020
Rat
RGD:1308844
367160
Dog
copine 4
VGNC:39563
485661
Species
Name
OMA
EggNOG
Inparanoid
Chimp
copine 4
Macaque
copine 4
Mouse
Rat
Dog
copine 4
Publication Statistics
PubMed Score 12.03
PubMed score by year
PubTator Score 2.00
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title