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Tchem
CPN1
Carboxypeptidase N catalytic chain

Protein Summary
Description
Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370418
  • ENSP00000359446
  • ENSG00000120054

Symbol
  • ACBP
  • CPN
  • SCPN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.64
protein domain
0.58
disease
0.56
molecular function
0.56
PubMedID
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.47   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.47   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (10)
Protein-Protein Interactions (47)
BTBD1
Tbio
Novelty:  0.19772296
p_int:  0.944360579
p_ni:  0.055639402
p_wrong:  1.9e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.917349148
p_ni:  0.082650852
Score:  0.171
Data Source:  BioPlex,STRINGDB
KDM3B
Tbio
Family:  Epigenetic
Novelty:  0.05322289
p_int:  0.875641302
p_ni:  0.123627345
p_wrong:  0.000731353
Score:  0.325
Data Source:  BioPlex,STRINGDB
CPN2
Tdark
Family:  Enzyme
Novelty:  0.52459343
Score:  0.993
Data Source:  Reactome,STRINGDB
C3
Tclin
Novelty:  0.00019115
Score:  0.958
Data Source:  Reactome,STRINGDB
C5
Tclin
Novelty:  0.00225386
Score:  0.952
Data Source:  Reactome,STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.819
Data Source:  STRINGDB
CPB2
Tchem
Family:  Enzyme
Novelty:  0.00164543
Score:  0.741
Data Source:  STRINGDB
TBCE
Tbio
Novelty:  0.01058281
Score:  0.716
Data Source:  STRINGDB
TBCD
Tbio
Novelty:  0.01161221
Score:  0.711
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
4
3
2
12.5
96.6
sex hormone-binding globulin measurement
6
3
6
92.1
interleukin-27 measurement
1
1
1
87.3
aspartate aminotransferase measurement
2
1
1
18.1
86.8
heel bone mineral density
2
2
3
79.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
2
12.5
96.6
sex hormone-binding globulin measurement
6
92.1
interleukin-27 measurement
1
87.3
aspartate aminotransferase measurement
1
18.1
86.8
heel bone mineral density
3
79.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
carboxypeptidase N subunit 1
709434
Mouse
MGI:2135874
93721
Rat
RGD:70931
365466
Dog
carboxypeptidase N subunit 1
VGNC:39558
477795
Horse
carboxypeptidase N subunit 1
VGNC:50662
100070412
Species
Name
OMA
EggNOG
Inparanoid
Macaque
carboxypeptidase N subunit 1
Mouse
Rat
Dog
carboxypeptidase N subunit 1
Horse
carboxypeptidase N subunit 1
Publication Statistics
PubMed Score 308.47
PubMed score by year
PubTator Score 159.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title