Protein Summary
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
- ENST00000338356
- ENSP00000339157
- ENSG00000135678
- ENST00000546373
- ENSP00000447255
- ENST00000551568
- ENSP00000448517
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
PubMedID | 0.91 | ||
kinase perturbation | 0.71 | ||
small molecule perturbation | 0.69 | ||
cell type or tissue | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 185.19 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 265 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 185.19 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 265 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (104)
ZSCAN12
Family: TF
Novelty: 0.33578207
p_int: 0.999992867
p_ni: 0.000007116
p_wrong: 1.7e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
ULBP1
Novelty: 0.01603533
p_int: 0.917711865
p_ni: 0.000296915
p_wrong: 0.08199122
Score: 0.345
Data Source: BioPlex,STRINGDB
FTH1
Novelty: 0.000863
p_int: 0.900032619
p_ni: 0.000017229
p_wrong: 0.099950151
Data Source: BioPlex
TBC1D22B
Novelty: 0.49852962
p_int: 0.855753068
p_ni: 0.000021617
p_wrong: 0.144225315
Data Source: BioPlex
GTPBP3
Family: Enzyme
Novelty: 0.08129502
p_int: 0.826491669
p_ni: 0.173508331
Score: 0.282
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational modification: synthesis of GPI-anchored proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational modification: synthesis of GPI-anchored proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 44.2 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 29 | |||||
red blood cell density measurement | 1 | 1 | 1 | 21.4 | |||||
mean corpuscular volume | 1 | 1 | 1 | 7.4 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 44.2 | |||||
mean reticulocyte volume | 1 | 29 | |||||
red blood cell density measurement | 1 | 21.4 | |||||
mean corpuscular volume | 1 | 7.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | carboxypeptidase M | VGNC:12901 | 452067 | |||||
Macaque | carboxypeptidase M | 718315 | ||||||
Mouse | MGI:1917824 | 70574 | ||||||
Rat | RGD:1310532 | 314855 | ||||||
Dog | carboxypeptidase M | VGNC:54521 | 100685525 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | carboxypeptidase M | |||||
Macaque | carboxypeptidase M | |||||
Mouse | ||||||
Rat | ||||||
Dog | carboxypeptidase M | |||||
Publication Statistics
PubMed Score 185.19
PubMed score by year
PubTator Score 64.00
PubTator score by year
Related Publications
Text Mined References (42)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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