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Tchem
CPM
Carboxypeptidase M

Protein Summary
Description
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338356
  • ENSP00000339157
  • ENSG00000135678
  • ENST00000546373
  • ENSP00000447255
  • ENST00000551568
  • ENSP00000448517
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.91
kinase perturbation
0.71
small molecule perturbation
0.69
cell type or tissue
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.19   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.19   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (104)
ZSCAN12
Tdark
Family:  TF
Novelty:  0.33578207
p_int:  0.999992867
p_ni:  0.000007116
p_wrong:  1.7e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
ULBP1
Tbio
Novelty:  0.01603533
p_int:  0.917711865
p_ni:  0.000296915
p_wrong:  0.08199122
Score:  0.345
Data Source:  BioPlex,STRINGDB
FTH1
Tbio
Novelty:  0.000863
p_int:  0.900032619
p_ni:  0.000017229
p_wrong:  0.099950151
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.855753068
p_ni:  0.000021617
p_wrong:  0.144225315
Data Source:  BioPlex
GTPBP3
Tbio
Family:  Enzyme
Novelty:  0.08129502
p_int:  0.826491669
p_ni:  0.173508331
Score:  0.282
Data Source:  BioPlex,STRINGDB
IZUMO1R
Tbio
Novelty:  0.02670576
Score:  0.918
Data Source:  STRINGDB
XPNPEP2
Tchem
Family:  Enzyme
Novelty:  0.01453123
Score:  0.912
Data Source:  STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.903
Data Source:  STRINGDB
ULBP2
Tbio
Novelty:  0.01604318
Score:  0.903
Data Source:  STRINGDB
LYPD6B
Tdark
Novelty:  0.1409054
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
44.2
mean reticulocyte volume
1
1
1
29
red blood cell density measurement
1
1
1
21.4
mean corpuscular volume
1
1
1
7.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
44.2
mean reticulocyte volume
1
29
red blood cell density measurement
1
21.4
mean corpuscular volume
1
7.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase M
VGNC:12901
452067
Macaque
carboxypeptidase M
718315
Mouse
MGI:1917824
70574
Rat
RGD:1310532
314855
Dog
carboxypeptidase M
VGNC:54521
100685525
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase M
Macaque
carboxypeptidase M
Mouse
Rat
Dog
carboxypeptidase M
Publication Statistics
PubMed Score 185.19
PubMed score by year
PubTator Score 64.00
PubTator score by year
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Related Publications
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PMID
Year
Title