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Tbio
CPLX3
Complexin-3

Protein Summary
Description
Positively regulates a late step in synaptic vesicle exocytosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395018
  • ENSP00000378464
  • ENSG00000213578

Symbol
  • CPXIII
  • CPX-III
  • Nbla11589
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.59
protein complex
0.57
PubMedID
0.51
cell type or tissue
0.49
disease
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.06   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.06   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.999843281
p_ni:  0.000156719
Data Source:  BioPlex
SIRT5
Tchem
Family:  Epigenetic
Novelty:  0.00225239
p_int:  0.997508282
p_ni:  0.002225127
p_wrong:  0.000266591
Score:  0.179
Data Source:  BioPlex,STRINGDB
ACPP
Tchem
Family:  Enzyme
Novelty:  0.00364265
p_int:  0.993543056
p_ni:  0.006102908
p_wrong:  0.000354036
Data Source:  BioPlex
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.9898937
p_ni:  0.0101063
Data Source:  BioPlex
LYG2
Tbio
Family:  Enzyme
Novelty:  0.12091256
p_int:  0.979941517
p_ni:  0.020058483
Data Source:  BioPlex
PKP3
Tbio
Novelty:  0.0269462
p_int:  0.979574898
p_ni:  0.020425092
p_wrong:  1e-8
Data Source:  BioPlex
CIAO1
Tbio
Novelty:  0.03999673
p_int:  0.977050581
p_ni:  0.022949419
Score:  0.163
Data Source:  BioPlex,STRINGDB
OTUB2
Tbio
Family:  Enzyme
Novelty:  0.00821431
p_int:  0.963630474
p_ni:  0.022775281
p_wrong:  0.013594244
Score:  0.195
Data Source:  BioPlex,STRINGDB
SERPINB5
Tbio
Novelty:  0.00192585
p_int:  0.959347235
p_ni:  0.040652758
p_wrong:  7e-9
Data Source:  BioPlex
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.958061024
p_ni:  0.041938945
p_wrong:  3.1e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (51)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
5
3
5
89.6
coffee consumption measurement
4
2
4
89
coffee consumption
5
3
6
88.6
glomerular filtration rate
4
2
6
82.7
creatinine measurement
2
2
3
82.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
5
89.6
coffee consumption measurement
4
89
coffee consumption
6
88.6
glomerular filtration rate
6
82.7
creatinine measurement
3
82.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2384571
235415
Rat
RGD:1560104
501005
Dog
complexin 3
VGNC:39557
611573
Horse
complexin 3
VGNC:16819
100062176
Cow
complexin 3
VGNC:27653
509248
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
complexin 3
Horse
complexin 3
Cow
complexin 3
Publication Statistics
PubMed Score 15.06
PubMed score by year
PubTator Score 4.01
PubTator score by year
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Related Publications
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PMID
Year
Title