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Tbio
CPLX1
Complexin-1

Protein Summary
Description
Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304062
  • ENSP00000305613
  • ENSG00000168993

Symbol
  • CPX1
  • CPX-I
  • EIEE63
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
tissue
0.62
transcription factor perturbation
0.61
gene perturbation
0.59
PubMedID
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.52   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.52   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (165)
CPLX2
Tbio
Novelty:  0.01821493
p_int:  0.999999976
p_ni:  2.4e-8
Score:  0.898
Data Source:  BioPlex,STRINGDB
VAMP3
Tbio
Novelty:  0.00694332
p_int:  0.922868393
p_ni:  0.077131347
p_wrong:  2.6e-7
Score:  0.841
Data Source:  BioPlex,STRINGDB
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.810195139
p_ni:  0.189750613
p_wrong:  0.000054248
Score:  0.173
Data Source:  BioPlex,STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.998
Data Source:  STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.998
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.996
Data Source:  STRINGDB
VAMP2
Tbio
Novelty:  0.00187736
Score:  0.988
Data Source:  STRINGDB
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
Score:  0.97
Data Source:  STRINGDB
SYT2
Tbio
Novelty:  0.00754735
Score:  0.969
Data Source:  STRINGDB
SYN2
Tbio
Novelty:  0.00574709
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
GABA synthesis, release, reuptake and degradation
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
GABA synthesis, release, reuptake and degradation
Glutamate Neurotransmitter Release Cycle
Neuronal System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
2
3
90.3
myeloid white cell count
2
2
2
89.7
monocyte percentage of leukocytes
2
2
2
89.5
leukocyte count
2
2
2
86.2
3
2
2
1.1
83.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
90.3
myeloid white cell count
2
89.7
monocyte percentage of leukocytes
2
89.5
leukocyte count
2
86.2
2
1.1
83.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
complexin 1
703519
Mouse
MGI:104727
12889
Rat
RGD:70944
64832
Dog
complexin 1
VGNC:39555
479134
Horse
complexin 1
VGNC:16817
100050943
Species
Name
OMA
EggNOG
Inparanoid
Macaque
complexin 1
Mouse
Rat
Dog
complexin 1
Horse
complexin 1
Publication Statistics
PubMed Score 73.52
PubMed score by year
PubTator Score 41.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title