Tbio CPEB4 Cytoplasmic polyadenylation element-binding protein 4

Protein Summary

Description

Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).

Uniprot Accession IDs

• Q17RY0
• B7ZLQ7
• Q7Z310
• Q8N405
• Q9C0J0
• CPE-BP4

Gene Name

• CPEB4

Ensembl ID

• ENST00000265085
• ENSP00000265085
• ENSG00000113742
• ENST00000334035
• ENSP00000334533
• ENST00000517880
• ENSP00000427990

Symbol

• KIAA1673
• CPE-BP4
• hCPEB-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
transcription factor binding site profile	0.93
small molecule perturbation	0.82
transcription factor perturbation	0.74
microRNA	0.7

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Polyadenylation Factor / Cytoplasmic Polyadenylation Element-binding Protein 4

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Polyadenylation Factor / Cytoplasmic Polyadenylation Element-binding Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.46   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 146   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.46   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0